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TTK inhibitor 3
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Catalog No. T72757Cas No. 2820453-41-4
TTK inhibitor 3 (compound 25) is a selective inhibitor of TTK (Threonine Tyrosine Kinase) with an IC50 of 3.0 nM for TTK and 16.0 nM for CAL-51 cells. It inhibits tumor growth in CAL-51 xenograft models and TNBC (triple-negative breast cancer) PDX models.
TTK inhibitor 3
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Purity: 99.44%
Catalog No. T72757Cas No. 2820453-41-4
TTK inhibitor 3 (compound 25) is a selective inhibitor of TTK (Threonine Tyrosine Kinase) with an IC50 of 3.0 nM for TTK and 16.0 nM for CAL-51 cells. It inhibits tumor growth in CAL-51 xenograft models and TNBC (triple-negative breast cancer) PDX models.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $588 | - | In Stock | |
| 5 mg | $1,280 | - | In Stock | |
| 10 mg | $1,730 | - | In Stock | |
| 25 mg | $2,570 | - | In Stock | |
| 50 mg | $3,380 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.44%
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Product Introduction
Bioactivity
Chemical Properties
| Description | TTK inhibitor 3 (compound 25) is a selective inhibitor of TTK (Threonine Tyrosine Kinase) with an IC50 of 3.0 nM for TTK and 16.0 nM for CAL-51 cells. It inhibits tumor growth in CAL-51 xenograft models and TNBC (triple-negative breast cancer) PDX models. |
| Targets&IC50 | CAL-51 cells:16.0 nM, TTK:3.0 nM |
| In vitro | TTK inhibitor 3 (compound 25) exhibited an IC50 of 3.0 nM against TTK and an IC50 of 16.0 nM against CAL-51 cells after 3 days of co-incubation [1]. |
| In vivo | Methods: In the CAL-51 mouse xenograft model, TTK inhibitor 3 was administered intravenously at 30, 40, and 50 mg/kg weekly for two weeks. Results: TTK inhibitor 3 exhibited dose-dependent increases in exposure and efficacy, with all treatment groups demonstrating significant (>60%) tumor growth inhibition and no observable body weight loss [1]. |
| Molecular Weight | 727.9 |
| Formula | C42H49N9O3 |
| Cas No. | 2820453-41-4 |
| Smiles | O=C1C2=CC(=CN2CCN1C=3C(=CC=CC3CC)CC)C=4N=C(N=C5NC=CC54)NC6=CC=C(C=C6OC)N7CCC(C(=O)N8CC9(C8)CN(C)C9)CC7 |
| Color | White |
| Appearance | Solid |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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