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Ponsegromab
(Synonyms: PF 06946860) Copy Product Info
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Synonyms: PF 06946860
Catalog No. T76774 Copy Product Info
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Ponsegromab (PF 06946860) is a selective and potent humanized anti-GDF15 antibody inhibitor with IC₅₀ values of 0.123 nM, 0.053 nM, and 0.102 nM for human, rhesus macaque, and mouse targets, respectively. Ponsegromab exhibits anti-cachexia activity by binding to GDF15 to prevent its interaction with GFRAL, thereby disrupting GDF15/GFRAL-mediated signaling. Ponsegromab possesses potential anticancer activity and may be used to treat cancer patients with cancer anorexia-cachexia syndrome. Ponsegromab acts as a chemopreparative agent, increasing intracellular reactive oxygen species levels and reducing glutathione levels.
Cas No. 2368950-15-4
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $297 | In Stock | In Stock | |
| 5 mg | $697 | In Stock | In Stock | |
| 10 mg | $1,120 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:100% (SEC-HPLC)
Appearance:Liquid
Color:Transparent
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| Description | Ponsegromab (PF 06946860) is a selective and potent humanized anti-GDF15 antibody inhibitor with IC₅₀ values of 0.123 nM, 0.053 nM, and 0.102 nM for human, rhesus macaque, and mouse targets, respectively. Ponsegromab exhibits anti-cachexia activity by binding to GDF15 to prevent its interaction with GFRAL, thereby disrupting GDF15/GFRAL-mediated signaling. Ponsegromab possesses potential anticancer activity and may be used to treat cancer patients with cancer anorexia-cachexia syndrome. Ponsegromab acts as a chemopreparative agent, increasing intracellular reactive oxygen species levels and reducing glutathione levels. |
| Targets & IC50 | GDF15:0.1095 μg/mL (EC50), GDF15-GFRAL:0.5037 μg/mL |
| In vivo | Methods: Adult C57BL/6J mice were injected intraperitoneally with LPS (10 mg/kg) to induce sepsis. Prior to LPS injection, the anti-GDF15 neutralizing antibody Ponsegromab (30 μg per mouse) was administered via lateral ventricle injection. Results: Ponsegromab significantly improved cognitive and memory function in septic mice (assessed via conditioned fear and novel object recognition tests), reduced hippocampal microglial activation and phagocytosis, and mitigated synaptic loss.[1] |
| Endotoxin | <1.0 EU/mg |
| Synonyms | PF 06946860 |
| Reactivity | Human |
| Verified Activity | 1. Immobilized Human GDF-15 Protein (His & HSA) can bind Ponsegromab. The EC50 is 3.834 ng/mL. 2. Immobilized Mouse GDF-15 Protein (His) can bind Ponsegromab. The EC50 is 5.7 ng/mL. 3. The binding of Human GDF-15 Protein (HSA & His) to the extracellular domain of biotinylated Human GFRAL Protein (Fc) can be blocked by Ponsegromab.  , , |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | GDF15/MIC1 |
| Molecular Weight | 146.08 kDa |
| Cas No. | 2368950-15-4 |
| Isotype | Human IgG1 kappa |
| Recommended Isotype Control |
| Storage | Store at low temperature -20°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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Related Tags: Ponsegromab chemical structure | Ponsegromab in vivo | Ponsegromab molecular weight
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