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Ponsegromab (Synonyms: PF 06946860)
Catalog No. T76774 Copy Product Info
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Ponsegromab (PF 06946860) is a selective and effective humanized anti-GDF15 antibody inhibitor with anti-cachexic activity. It binds to GDF15, preventing its interaction with GFRAL and disrupting GDF15/GFRAL mediated signaling. Ponsegromab has potential anticancer activity and can be used to treat cancer patients with cancer anorexia cachexia syndrome.
Ponsegromab
Copy Product Info🥰Excellent
Catalog No. T76774
Synonyms PF 06946860
Ponsegromab (PF 06946860) is a selective and effective humanized anti-GDF15 antibody inhibitor with anti-cachexic activity. It binds to GDF15, preventing its interaction with GFRAL and disrupting GDF15/GFRAL mediated signaling. Ponsegromab has potential anticancer activity and can be used to treat cancer patients with cancer anorexia cachexia syndrome.
Ponsegromab
Cas No. 2368950-15-4
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $297 | In Stock | In Stock | |
| 5 mg | $697 | In Stock | In Stock | |
| 10 mg | $1,120 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:100% (SEC-HPLC)
Appearance:Liquid
Color:Transparent
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| Description | Ponsegromab (PF 06946860) is a selective and effective humanized anti-GDF15 antibody inhibitor with anti-cachexic activity. It binds to GDF15, preventing its interaction with GFRAL and disrupting GDF15/GFRAL mediated signaling. Ponsegromab has potential anticancer activity and can be used to treat cancer patients with cancer anorexia cachexia syndrome. |
| Targets&IC50 | GDF15-GFRAL:0.5037 μg/mL, GDF15:0.1095 μg/mL (EC50) |
| Synonyms | PF 06946860 |
| Reactivity | Human |
| Verified Activity | 1. Immobilized Human GDF-15 Protein (His & HSA) can bind Ponsegromab. The EC50 is 3.834 ng/mL. 2. Immobilized Mouse GDF-15 Protein (His) can bind Ponsegromab. The EC50 is 5.7 ng/mL. 3. The binding of Human GDF-15 Protein (HSA & His) to the extracellular domain of biotinylated Human GFRAL Protein (Fc) can be blocked by Ponsegromab.    |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | GDF15/MIC1 |
| Molecular Weight | 146.08 kDa |
| Cas No. | 2368950-15-4 |
| Isotype | Human IgG1 kappa |
| Recommended Isotype Control |
| Storage | store at low temperature | -20°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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