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Stevioside

Name: Stevioside
Brand: TargetMol
SKU: T2911
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2911Cas No. 57817-89-7

A natural, noncaloric sweetener with a potency 300 times more than that of regular sucrose. Exhibits transepithelial p-aminohippurate transport via organic anion transport system interference.

Stevioside

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Purity: 99.89%

Catalog No. T2911Cas No. 57817-89-7

A natural, noncaloric sweetener with a potency 300 times more than that of regular sucrose. Exhibits transepithelial p-aminohippurate transport via organic anion transport system interference.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$35	In Stock	In Stock
50 mg	$52	In Stock	In Stock
100 mg	$77	In Stock	In Stock
500 mg	$187	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.89%

Color:White to Yellow

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COA HNMR LCMS

Product Introduction

Stevioside AI Summary

Stevioside exhibits multiple bioactivities, including inhibition of HIV1 reverse transcriptase (IC50 >200.0 µg/mL) and cytotoxicity against human Raji cells (cell viability 60.0%). The compound shows potent inhibition of TPA-induced EBV-early antigen activation in human Raji cells, with activities ranging from 100.0% at a 10 molar ratio to 12.5% at a 1000 molar ratio. It also demonstrates antioxidant activity with a hydroxyl radical scavenging IC50 value of 1500000.0 nM, and agonist activity at the glucocorticoid receptor in mouse RAW264.7 cells, with a firefly/renilla luciferase ratio of 1.96 at 10 µM concentration. In sensory evaluations, Stevioside displays sweet taste properties at 500 p.p.m., with a sweetness intensity relative to 10% sucrose (Ip = 0.9), high potency by weight (Pw = 190.0), and molar basis (Pm = 440.0). The sensory scores are 62.0 for sweetness, 30.0 for bitterness, and 8.0 for other properties. In animal models, Stevioside shows varied bioactivities related to renal excretion in Wistar rats, influencing renal clearance and excretion mechanisms depending on dosage. It also induces insulin sensitivity in Syrian golden hamsters, increasing glucose uptake 2.1-fold under normal conditions and 4.4-fold under insulin-resistant conditions, while downregulating glucose uptake in the jejunum by 43.0% at 1 mM after 60 minutes. Additionally, the compound inhibits DMBA-induced/TPA-promoted and peroxynitrite-induced/TPA-promoted carcinogenesis in Sencar mice, reducing the number of skin papillomas per mouse and showing reductions after a 20-week treatment duration. In terms of toxicity, Stevioside displays acute toxicity in mice with LD50 values greater than 15000.0 mg/kg and 8200.0 mg/kg for different assessments..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

A natural, noncaloric sweetener with a potency 300 times more than that of regular sucrose. Exhibits transepithelial p-aminohippurate transport via organic anion transport system interference.

Chemical Properties

Molecular Weight	804.87
Formula	C₃₈H₆₀O₁₈
Cas No.	57817-89-7
Smiles	C[C@@]12CCC[C@](C)(C1CC[C@@]13CC(=C)[C@](C1)(CCC23)O[C@H]1O[C@H](CO)C(O)[C@H](O)[C@H]1O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C(=O)O[C@@H]1O[C@H](CO)C(O)[C@H](O)C1O
Relative Density.	1.53 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80.5 mg/mL (100.02 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (4.1 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.2424 mL	6.2122 mL	12.4244 mL	62.1218 mL
5 mM	0.2485 mL	1.2424 mL	2.4849 mL	12.4244 mL
10 mM	0.1242 mL	0.6212 mL	1.2424 mL	6.2122 mL
20 mM	0.0621 mL	0.3106 mL	0.6212 mL	3.1061 mL
50 mM	0.0248 mL	0.1242 mL	0.2485 mL	1.2424 mL
100 mM	0.0124 mL	0.0621 mL	0.1242 mL	0.6212 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc