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3-Deazauridine

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Catalog No. T36866Cas No. 23205-42-7
Alias NSC 126849

3-Deazauridine (NSC-126849) is a structural analog of uridine that inhibits the biosynthesis of Cytidine-5'-Triphosphate by competitive inhibition of Cytidine Triphosphate synthetase which is considered to be the primary mode of action of this nucleoside analog.

3-Deazauridine

3-Deazauridine

🥰Excellent
Purity: 99.86%
Catalog No. T36866Alias NSC 126849Cas No. 23205-42-7
3-Deazauridine (NSC-126849) is a structural analog of uridine that inhibits the biosynthesis of Cytidine-5'-Triphosphate by competitive inhibition of Cytidine Triphosphate synthetase which is considered to be the primary mode of action of this nucleoside analog.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
25 mg$48In StockIn Stock
50 mg$77In StockIn Stock
100 mg$118In StockIn Stock
200 mg$178In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.86%
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Product Introduction

Bioactivity
Description
3-Deazauridine (NSC-126849) is a structural analog of uridine that inhibits the biosynthesis of Cytidine-5'-Triphosphate by competitive inhibition of Cytidine Triphosphate synthetase which is considered to be the primary mode of action of this nucleoside analog.
In vitro
3-Deazauridine enhanced the in vitro antineoplastic action of 5-AZA-CdR on human leukemic cells by increasing its incorporation into DNA. Using an optimized dose-schedule we showed that this combination could cure some mice bearing L1210 leukemia, even in the presence of a subpopulation of drug-resistant (L1210/ARA-C) leukemic cells lacking DCK. 3-Deazauridine alone also cured some mice with L1210/ARA-C leukemia[1].
SynonymsNSC 126849
Chemical Properties
Molecular Weight243.21
FormulaC10H13NO6
Cas No.23205-42-7
SmilesO[C@H]1[C@@H](O[C@H](CO)[C@H]1O)N2C(=O)C=C(O)C=C2
Relative Density.1.718 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 45 mg/mL (185.03 mM), Sonication is recommended.
DMF: 16 mg/mL (65.79 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (8.22 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMF/DMSO
1mg5mg10mg50mg
1 mM4.1117 mL20.5584 mL41.1167 mL205.5837 mL
5 mM0.8223 mL4.1117 mL8.2233 mL41.1167 mL
10 mM0.4112 mL2.0558 mL4.1117 mL20.5584 mL
20 mM0.2056 mL1.0279 mL2.0558 mL10.2792 mL
50 mM0.0822 mL0.4112 mL0.8223 mL4.1117 mL
DMSO
1mg5mg10mg50mg
100 mM0.0411 mL0.2056 mL0.4112 mL2.0558 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
mg/kg
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μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

NucleosideAntimetaboliteNucleoside Antimetabolite/AnalogNucleoside AntimetaboliteNSC-126849NSC126849Analog3-Deazauridine3Deazauridine3 Deazauridine
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