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Dimenhydrinate

Name: Dimenhydrinate
Brand: TargetMol
SKU: T0298
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0298Cas No. 523-87-5

Alias Vomex A, Dramamine, Chloranautine

Dimenhydrinate (Vomex A) is an ethanolamine and histamine antagonist with anti-allergic activity.

Dimenhydrinate

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Purity: 99.77%

Catalog No. T0298Alias Vomex A, Dramamine, ChloranautineCas No. 523-87-5

Dimenhydrinate (Vomex A) is an ethanolamine and histamine antagonist with anti-allergic activity.

Pack Size	Price	USA Warehouse	Global Warehouse
100 mg	$31	In Stock	In Stock
200 mg	$44	In Stock	In Stock
500 mg	$70	In Stock	In Stock
1 g	$98	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$50	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.77%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Dimenhydrinate AI Summary

Dimenhydrinate exhibits a diverse range of bioactivities across multiple biochemical assays and targets. It demonstrates significant potency in inducing erasure of genomic imprints, inhibiting Aldehyde Dehydrogenase 1 (ALDH1A1), and Hydroxyacyl-Coenzyme A Dehydrogenase, Type II (HADH2). Additionally, it is a substrate of Cytochrome P450 2D6 and shows bioactivity in Cytochrome panel assays. The compound acts as an agonist for androgen receptor signaling and the antioxidant response element (ARE) signaling pathway. Moreover, it inhibits the human hERG channel activity and the ROR-gamma signaling pathway. Dimenhydrinate has activity against various adrenergic receptors, the norepinephrine transporter, calcium channel Type L, and dopamine transporter. It also shows notable activity in histamine H1 receptor, serotonin receptor subtypes (5-HT2A, 5-HT2B, and 5-HT2C), and Sigma1 receptor binding assays, indicating broad pharmacological effects. It further inhibits sodium fluorescein uptake in OATP1B3 and OATP1B1-transfected CHO cells. Evaluation in DrugMatrix assays illustrates alterations in several physiological parameters like liver enzymes, kidney function markers, electrolytes, lipid profiles, hematological parameters, and immune cell counts, suggesting potential effects on liver and kidney function, blood composition, and immune response. For biliary transport, Dimenhydrinate shows weak or no inhibitory effect on human BSEP, MRP2, MRP3, and MRP4 activities, with IC50 values substantially higher than effective concentrations. It induces no drug-induced liver injury. In antiviral studies, Dimenhydrinate shows moderate to weak inhibition of SARS-CoV-2 cytotoxicity and 3CL-Pro protease activity, identifiable by varying inhibition values across different assays at tested concentrations. The compound has also shown selective inhibition of the HDAC6 enzyme, suggesting potential as an HDAC6 inhibitor based on assays utilizing different peptide substrates..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Dimenhydrinate (Vomex A) is an ethanolamine and histamine antagonist with anti-allergic activity.
Synonyms	Vomex A, Dramamine, Chloranautine

Chemical Properties

Molecular Weight	469.96
Formula	C₂₄H₂₈ClN₅O₃
Cas No.	523-87-5
Smiles	Cn1c2c([nH]c(Cl)n2)c(=O)n(C)c1=O.CN(C)CCOC(c1ccccc1)c1ccccc1
Relative Density.	1.2586 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (127.67 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.26 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1278 mL	10.6392 mL	21.2784 mL	106.3920 mL
5 mM	0.4256 mL	2.1278 mL	4.2557 mL	21.2784 mL
10 mM	0.2128 mL	1.0639 mL	2.1278 mL	10.6392 mL
20 mM	0.1064 mL	0.5320 mL	1.0639 mL	5.3196 mL
50 mM	0.0426 mL	0.2128 mL	0.4256 mL	2.1278 mL
100 mM	0.0213 mL	0.1064 mL	0.2128 mL	1.0639 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc