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CYM-5478
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Catalog No. T27107Cas No. 870762-83-7
Alias CYM5478, CYM 5478
CYM-5478 is a highly selective S1P2 agonist with an EC50 value of 119 nM in the TGF-α detachment test and can reduce the toxicity of cisplatin to neurogenic cell lines.
CYM-5478
😃Good
Catalog No. T27107Alias CYM5478, CYM 5478Cas No. 870762-83-7
CYM-5478 is a highly selective S1P2 agonist with an EC50 value of 119 nM in the TGF-α detachment test and can reduce the toxicity of cisplatin to neurogenic cell lines.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $268 | 35 days | 35 days | |
| 5 mg | $640 | 35 days | 35 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
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Chemical Properties
Storage & Solubility Information
| Description | CYM-5478 is a highly selective S1P2 agonist with an EC50 value of 119 nM in the TGF-α detachment test and can reduce the toxicity of cisplatin to neurogenic cell lines. |
| Targets&IC50 | S1P3 receptor:1950 nM (EC50), S1P4 receptor:> 10 μM (EC50), S1P2 receptor:119 nM (EC50), S1P5 receptor:> 10 μM (EC50), S1P1 receptor:1690 nM (EC50) |
| In vitro | CYM-5478 (1, 10, 100, 1000, 10000 nM) induces a statistically significant increase in the viability of C6 cells in a dose dependent manner at concentrations above 100 nM under nutrient-deprivation stress produced by serum-starvation. This effect was absent in the presence of 10% fetal bovine serum[1]. CYM-5478 (10 μM) causes significantly attenuated the increase of ROS in C6 cells exposed to Cisplatin (20 μM; for 24 hours)[1]. CYM-5478 (20 μM) protects neural cells but not breast cancer cells against Cisplatin toxicity (C6 glioma cells: EC50=4.54 μM; GT1-7: EC50=17 μM; SK-N-BE2: EC50=7.44 μM; CLU188: EC50=5.54 μM)[2]. |
| In vivo | CYM-5478 (1 mg/kg/day; ip) protects against Cisplatin-mediated (3 mg/kg; i.p.; once a week for 3 week) ototoxicity in rats[2]. CYM-5478 (20 μM) provides near-complete protection against cisplatin-induced loss of viability in hair cells within the zebrafish ototoxicity model [2]. |
| Synonyms | CYM5478, CYM 5478 |
| Molecular Weight | 388.38 |
| Formula | C21H19F3N2O2 |
| Cas No. | 870762-83-7 |
| Smiles | O=C1C=CC(=CN1CC(=O)C=2C=C(N(C2C)CC=3C=CC=CC3)C)C(F)(F)F |
| Relative Density. | 1.23 g/cm3 (Predicted) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL (205.98 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Stock solution preparation method: 2 mg of drug dissolved in 50 μL DMSO (stock solution concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(stock solution concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyThe above example illustrates how to use "In Vivo Formulation Calculator" and does not represent a recommended formulation for any specific compound. Please select an appropriate dissolution method based on your experimental animals and route of administration.
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