Shopping Cart

Your shopping cart is currently empty

CYM-5478

Name: CYM-5478
Brand: TargetMol
SKU: T27107
Price: 73 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

😃Good

Catalog No. T27107Cas No. 870762-83-7

Alias CYM5478, CYM 5478

CYM-5478 is a highly selective S1P2 agonist with an EC50 value of 119 nM in the TGF-α detachment test and can reduce the toxicity of cisplatin to neurogenic cell lines.

CYM-5478

Copy Product Info

😃Good

Purity: 99.92%

Catalog No. T27107Alias CYM5478, CYM 5478Cas No. 870762-83-7

CYM-5478 is a highly selective S1P2 agonist with an EC50 value of 119 nM in the TGF-α detachment test and can reduce the toxicity of cisplatin to neurogenic cell lines.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$73	-	In Stock
5 mg	$278	-	In Stock
10 mg	$393	-	In Stock
25 mg	$693	-	In Stock
50 mg	$993	-	In Stock
100 mg	$1,380	-	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.92%

Resource Download

Product Introduction

Bioactivity

Description	CYM-5478 is a highly selective S1P2 agonist with an EC50 value of 119 nM in the TGF-α detachment test and can reduce the toxicity of cisplatin to neurogenic cell lines.
Targets&IC50	S1P3 receptor:1950 nM (EC50), S1P2 receptor:119 nM (EC50), S1P1 receptor:1690 nM (EC50), S1P5 receptor:> 10 μM (EC50), S1P4 receptor:> 10 μM (EC50)
In vitro	CYM-5478 (1, 10, 100, 1000, 10000 nM) induces a statistically significant increase in the viability of C6 cells in a dose dependent manner at concentrations above 100 nM under nutrient-deprivation stress produced by serum-starvation. This effect was absent in the presence of 10% fetal bovine serum[1]. CYM-5478 (10 μM) causes significantly attenuated the increase of ROS in C6 cells exposed to Cisplatin (20 μM; for 24 hours)[1]. CYM-5478 (20 μM) protects neural cells but not breast cancer cells against Cisplatin toxicity (C6 glioma cells: EC50=4.54 μM; GT1-7: EC50=17 μM; SK-N-BE2: EC50=7.44 μM; CLU188: EC50=5.54 μM)[2].
In vivo	CYM-5478 (1 mg/kg/day; ip) protects against Cisplatin-mediated (3 mg/kg; i.p.; once a week for 3 week) ototoxicity in rats[2]. CYM-5478 (20 μM) provides near-complete protection against cisplatin-induced loss of viability in hair cells within the zebrafish ototoxicity model [2].
Synonyms	CYM5478, CYM 5478

Chemical Properties

Molecular Weight	388.38
Formula	C₂₁H₁₉F₃N₂O₂
Cas No.	870762-83-7
Smiles	O=C1C=CC(=CN1CC(=O)C=2C=C(N(C2C)CC=3C=CC=CC3)C)C(F)(F)F
Relative Density.	1.23 g/cm3 (Predicted)

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (205.98 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5748 mL	12.8740 mL	25.7480 mL	128.7399 mL
5 mM	0.5150 mL	2.5748 mL	5.1496 mL	25.7480 mL
10 mM	0.2575 mL	1.2874 mL	2.5748 mL	12.8740 mL
20 mM	0.1287 mL	0.6437 mL	1.2874 mL	6.4370 mL
50 mM	0.0515 mL	0.2575 mL	0.5150 mL	2.5748 mL
100 mM	0.0257 mL	0.1287 mL	0.2575 mL	1.2874 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc