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Synonyms: GPRC5D

| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 µg | $490 | 7-10 days | 7-10 days | |
| 20 µg | $838 | 7-10 days | 7-10 days | |
| 50 µg | $1,230 | 7-10 days | 7-10 days | |
| 100 µg | $1,930 | 7-10 days | 7-10 days | |
| 200 µg | $2,750 | 7-10 days | 7-10 days | |
| 500 µg | $6,150 | 7-10 days | 7-10 days |
| Bioactivity | Immobilized Biotinylated Human GPRC5D-VLP (Full Length) Protein at 5 μg/mL (100 μL/well) on streptavidin precoated (2 μg/well) can bind Anti-Human GPRC5D Antibody, Human IgG1, the EC50 is 4-12ng/mL. |
| Description | GPRC5D Protein, Human, Recombinant, Biotinylated is expressed in HEK293 mammalian cells. The predicted molecular weight is 38.80 kDa and the accession number is Q9NZD1-1. |
| Species | Human |
| Expression System | HEK293 Cells |
| Tag | Tag Free |
| Accession Number | Q9NZD1-1 |
| Construction | A DNA sequence encoding the human GPRC5D (Q9NZD1-1) (Met1-Val345) was expressed. Predicted N terminal: Met 1 |
| Endotoxin | < 1.0 EU/μg of the protein as determined by the LAL method. |
| Formulation | Supplied as sterile solution in 50 mM HEPES, 150 mM NaCI, 10% Trehalose, pH 7.2. |
| Synonyms | GPRC5D |
| Research Background | Orphan G-protein-coupled receptor family C group 5 member D (GPRC5D) has seven transmembrane segments forming the core of the receptor, as well as an intracellular C-tail and an extracellular N-terminal domain. GPRC5D is highly and selectively expressed on the surface of CD138+ multiple myeloma (MM) cells, whereas in normal tissues, a much lower expression is limited to plasma cells and certain hard keratinizing tissues. This makes GPRC5D a promising marker for monitoring tumor load and a target antigen for MM-specific T cell-engaging therapies such as bispecific antibodies and CAR-T cells. |
| Molecular Weight | 38.80 kDa (predicted) |
| Shipping | Proteins are shipped with blue ice. |
| Storage | It is recommended to store the product under sterile conditions at -70°C or lower. Samples are stable for up to 12 months at -80°C. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
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