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L-Glutamic acid

Name: L-Glutamic acid
Brand: TargetMol
SKU: T2A2497
Price: 42 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2A2497Cas No. 56-86-0

Alias glutamic acid, glutacid, (S)-Glutamic acid, (+)-L-Glutamic acid

L-Glutamic acid is an excitatory amino acid neurotransmitter and a Glutamic acid receptor agonist, including metabolic glutamic acid receptor (mGluR), AMPA receptor, NMDA receptor and KA receptor. L-Glutamic acid has an excitatory effect on the process of DA release from dopaminergic nerve endings. L-Glutamic acid can be used in the research of neurological diseases. L-Glutamic acid acts on ionic and metabolic Glutamic acid receptors.

L-Glutamic acid

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Purity: 99.55%

Catalog No. T2A2497Alias glutamic acid, glutacid, (S)-Glutamic acid, (+)-L-Glutamic acidCas No. 56-86-0

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
5 g	$42	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.55%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR HPLC

Product Introduction

L-Glutamic acid AI Summary

L-Glutamic acid exhibits a diverse array of bioactivities across various glutamate receptors and related systems. It acts as an agonist at metabotropic glutamate receptors (mGluRs), showing potencies indicated by EC50 values of 610.0 nM for mGluR2 and 1050.0 nM for mGluR1. It also exhibits antagonist activity against NMDA receptors with an IC50 value of 70.0 nM and at AMPA receptors with an IC50 value of 340.0 nM. In assays, L-Glutamic acid demonstrates potent inhibition of glutamate transporters, particularly EAAT1, EAAT2, and EAAT3, with IC50 values ranging from 11,000 nM to 50,118 nM. It shows binding affinities toward AMPA receptors (IC50 = 1300.0 nM), kainate receptors (IC50 = 700.0 nM), and NMDA receptors (IC50 = 200.0 nM), suggesting a broad spectrum impact on the glutamatergic system. Additionally, the compound has demonstrated bioactivity influencing ionotropic glutamate receptors, with different nanomolar range affinities for AMPA, kainate, and NMDA receptor subtypes, and showing agonistic activities in calcium influx assays in various receptor mutants expressed in HEK293 cells. The calculated pKa values (2.23, 4.21, and 9.54) and a partition coefficient (logP) of 3.88 suggest that L-Glutamic acid is moderately lipophilic and capable of crossing cell membranes. Overall, L-Glutamic acid's broad-ranging modulatory effects on multiple glutamate receptor subtypes and its varied affinity and potency in different assays and receptors illustrate its potential as a multi-target compound in neurological and pharmacological research..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	L-Glutamic acid is an excitatory amino acid neurotransmitter and a Glutamic acid receptor agonist, including metabolic glutamic acid receptor (mGluR), AMPA receptor, NMDA receptor and KA receptor. L-Glutamic acid has an excitatory effect on the process of DA release from dopaminergic nerve endings. L-Glutamic acid can be used in the research of neurological diseases. L-Glutamic acid acts on ionic and metabolic Glutamic acid receptors.
Targets&IC50	CHO cells:1.2 μM, HEK293 cells:0.06 μM, BHK-21 cells:1.8 μM (EC50), Oocyte:0.45 μM
In vitro	METHODS: SH-SY5Y cells were treated with L-Glutamic acid (10, 20, 30 mM) for 3 hours, and cell viability was detected using the MTT assay. RESULTS: L-Glutamic acid reduced the viability of SH-SY5Y cells. [1]
Synonyms	glutamic acid, glutacid, (S)-Glutamic acid, (+)-L-Glutamic acid

Chemical Properties

Molecular Weight	147.13
Formula	C₅H₉NO₄
Cas No.	56-86-0
Smiles	[C@H](CCC(O)=O)(C(O)=O)N
Relative Density.	1.54 g/cm3. Temperature:20 °C.

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 8.27 mg/mL (56.21 mM), Sonication is recommended.

DMSO: < 1 mg/mL (insoluble or slightly soluble)

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	6.7967 mL	33.9836 mL	67.9671 mL	339.8355 mL
5 mM	1.3593 mL	6.7967 mL	13.5934 mL	67.9671 mL
10 mM	0.6797 mL	3.3984 mL	6.7967 mL	33.9836 mL
20 mM	0.3398 mL	1.6992 mL	3.3984 mL	16.9918 mL
50 mM	0.1359 mL	0.6797 mL	1.3593 mL	6.7967 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc