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Rabeprazole
🥰Excellent
Catalog No. T19826Cas No. 117976-89-3
Alias LY307640
Rabeprazole (LY307640) is an H+/K+-ATPase inhibitor that inhibits cell proliferation in gastric epithelial cells by targeting STAT3-mediated glycolysis and can be used in the study of gastric ulcers.
Rabeprazole
🥰Excellent
Purity: 97.06%
Catalog No. T19826Alias LY307640Cas No. 117976-89-3
Rabeprazole (LY307640) is an H+/K+-ATPase inhibitor that inhibits cell proliferation in gastric epithelial cells by targeting STAT3-mediated glycolysis and can be used in the study of gastric ulcers.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $31 | In Stock | |
| 10 mg | $48 | In Stock | |
| 25 mg | $77 | In Stock | |
| 50 mg | $113 | In Stock |
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Purity:97.06%
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Product Introduction
Bioactivity
Chemical Properties
| Description | Rabeprazole (LY307640) is an H+/K+-ATPase inhibitor that inhibits cell proliferation in gastric epithelial cells by targeting STAT3-mediated glycolysis and can be used in the study of gastric ulcers. |
| Targets&IC50 | UNH:0.3 μM (IC50) |
| In vitro | Rabeprazole was administered to three gastric cancer cell lines, KATO III, MKN-28, and MKN-45, at a dosage of 0.2 mM under acidic conditions for 16 hours. The results showed that rabeprazole exerted a strong inhibitory effect on the proliferation of gastric cancer cells[2]. |
| In vivo | The results of rabeprazole (10 mg/kg; oral administration; every 48 hours for 18 weeks) showed significantly lower serum calcium levels compared to the vehicle-treated group in Swiss albino mice[3]. |
| Synonyms | LY307640 |
| Molecular Weight | 359.44 |
| Formula | C18H21N3O3S |
| Cas No. | 117976-89-3 |
| Smiles | COCCCOc1ccnc(CS(=O)c2nc3ccccc3[nH]2)c1C |
| Relative Density. | 1.33 g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: 5 mg/mL (13.91 mM), Sonication is recommended. | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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