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GLUT1/EGFR-IN-1

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Catalog No. T88616Cas No. 2393787-80-7

GLUT1/EGFR-IN-1 (compound H) is a potent inhibitor of both GLUT1 and EGFR. It targets the ATP-binding site of the EGFR tyrosine kinase and inhibits GLUT1-mediated energy metabolism, resulting in reduced ATP, MMP, intracellular lactate, and nuclear translocation of EGFR. GLUT1/EGFR-IN-1 is applicable in the research of nasopharyngeal carcinoma (NPC) and triple-negative breast cancer (TNBC).

GLUT1/EGFR-IN-1

GLUT1/EGFR-IN-1

😃Good
Catalog No. T88616Cas No. 2393787-80-7
GLUT1/EGFR-IN-1 (compound H) is a potent inhibitor of both GLUT1 and EGFR. It targets the ATP-binding site of the EGFR tyrosine kinase and inhibits GLUT1-mediated energy metabolism, resulting in reduced ATP, MMP, intracellular lactate, and nuclear translocation of EGFR. GLUT1/EGFR-IN-1 is applicable in the research of nasopharyngeal carcinoma (NPC) and triple-negative breast cancer (TNBC).
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
25 mg$1,6708-10 weeks8-10 weeks
50 mg$2,1808-10 weeks8-10 weeks
100 mg$2,8008-10 weeks8-10 weeks
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Product Introduction

Bioactivity
Description
GLUT1/EGFR-IN-1 (compound H) is a potent inhibitor of both GLUT1 and EGFR. It targets the ATP-binding site of the EGFR tyrosine kinase and inhibits GLUT1-mediated energy metabolism, resulting in reduced ATP, MMP, intracellular lactate, and nuclear translocation of EGFR. GLUT1/EGFR-IN-1 is applicable in the research of nasopharyngeal carcinoma (NPC) and triple-negative breast cancer (TNBC).
In vitro
GLUT1/EGFR-IN-1 (compound H) exhibits strong antitumor activity in CNE1 and MDA-MB231 cells with IC 50 values below 3 µmol/L, though its efficacy is less pronounced in CNE2 cells. In the presence of GLUT1/EGFR-IN-1 (0-4 μM, 48 hours), the expression of EGFR and p-EGFR is inhibited in both CNE1 and MDA-MB231 cells. Additionally, GLUT1/EGFR-IN-1 (0-4 μM, 48 hours) induces apoptosis in these cells.
In vivo
Compound H (GLUT1/EGFR-IN-1) administered intraperitoneally (IP) at doses of 4-8 mg/kg over a period of two weeks inhibits the growth of MDA-MB231 transplanted tumor cells in a nude mouse model. This study utilized BALB/c-neu female mice, aged four to five weeks and numbering five in total, to examine the compound's efficacy.
Chemical Properties
Molecular Weight696.75
FormulaC44H32N4O5
Cas No.2393787-80-7
SmilesO=C(NC=1C=CC2=NC=NC(NC3=CC=C(C=C3)C)=C2C1)C4=CC(OCC=5C=CC=CC5)=C6C(=O)C=7C(OCC=8C=CC=CC8)=CC=CC7C(=O)C6=C4
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
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2 Enter the in vivo formulation:
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