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SAR131675

Name: SAR131675
Brand: TargetMol
SKU: T6012
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T6012Cas No. 1433953-83-3

Alias SAR 131675

SAR131675 is a potent and selective VEGFR3 inhibitor with an IC50 of 23 nM.

SAR131675

🥰Excellent

Purity: 99.74%

Catalog No. T6012Alias SAR 131675Cas No. 1433953-83-3

SAR131675 is a potent and selective VEGFR3 inhibitor with an IC50 of 23 nM.

Pack Size	Price	Availability
1 mg	$30	In Stock
5 mg	$67	In Stock
10 mg	$115	In Stock
25 mg	$238	In Stock
50 mg	$362	In Stock
100 mg	$543	In Stock
200 mg	$653	In Stock
1 mL x 10 mM (in DMSO)	$78	In Stock

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Batch Information

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Purity:99.74%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	SAR131675 is a potent and selective VEGFR3 inhibitor with an IC50 of 23 nM.
Targets&IC50	VEGFR3:23 nM
Synonyms	SAR 131675

Chemical Properties

Molecular Weight	358.39
Formula	C₁₈H₂₂N₄O₄
Cas No.	1433953-83-3
Smiles	C(C)N1C=2C(C(=O)C(C(NC)=O)=C1N)=CC=C(C#C[C@@](COC)(C)O)N2
Relative Density.	1.33 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 70 mg/mL (195.32 mM), when pH is adjusted to 2 with HCl. Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7903 mL	13.9513 mL	27.9026 mL	139.5128 mL
5 mM	0.5581 mL	2.7903 mL	5.5805 mL	27.9026 mL
10 mM	0.2790 mL	1.3951 mL	2.7903 mL	13.9513 mL
20 mM	0.1395 mL	0.6976 mL	1.3951 mL	6.9756 mL
50 mM	0.0558 mL	0.2790 mL	0.5581 mL	2.7903 mL
100 mM	0.0279 mL	0.1395 mL	0.2790 mL	1.3951 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc