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m-Coumaric acid

Name: m-Coumaric acid
Brand: TargetMol
SKU: T19408
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T19408Cas No. 588-30-7

Turanose is a naturally occurring isomer of sucrose found in honey. It has anti-inflammatory and fat-regulating activities. It has research potential for obesity and related chronic diseases.

m-Coumaric acid

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Purity: 99.82%

Catalog No. T19408Cas No. 588-30-7

Turanose is a naturally occurring isomer of sucrose found in honey. It has anti-inflammatory and fat-regulating activities. It has research potential for obesity and related chronic diseases.

Pack Size	Price	USA Warehouse	Global Warehouse
200 mg	$33	In Stock	In Stock
500 mg	$50	In Stock	In Stock
1 g	$70	-	In Stock
5 g	$163	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.82%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

m-Coumaric acid AI Summary

m-Coumaric acid exhibits a diverse range of bioactivities across various biological systems. It demonstrates significant inhibition of alpha-glucosidase with an IC50 value of 1,270,000 nM, and shows high potency as an HDAC inhibitor in human HeLa cells nuclear extracts with 96.0% activity at 500 µM, suggesting its potential in epigenetic regulation and cancer therapy. Additionally, it is a potent inhibitor of Protobothrops flavoviridis venom-induced hemorrhage in ddY mice with an IC50 value of 180 nM. However, m-Coumaric acid shows low bioactivity in other assays, including only 1.0% inhibition of beta-hexosaminidase release from RBL-2H3 cells at 100 µM, and low inhibition of nitric oxide production in activated macrophages, with an IC50 greater than 100,000 nM and 3.0% inhibition at 100 µM. It also shows poor activity in the displacement of [3H]nicotinic acid from GPR109a receptor and in inhibiting Pseudomonas aeruginosa recombinant PqsD activity. In herbicidal assays, m-Coumaric acid displays strong activity against radish seed germination, showing 100% inhibition at 200 ppm. It also inhibits pyruvate uptake in Xenopus laevis oocytes with 20%-30% activity and shows slight antibacterial activity against Mycobacterium species, with MIC values ranging from >600,000 nM to 366,000 nM, and a selectivity index of 14.5 against Mycobacterium tuberculosis H37Rv. m-Coumaric acid interacts with beta cyclodextrin (log Ks = 2.56), inhibits self-induced amyloid beta aggregation (IC50 > 100,000 nM), and shows distinct electrochemical behavior with a peak potential of 780 mV. Its antioxidant activity is reflected in a DPPH free radical scavenging activity with an EC50 > 300,000 nM. The compound also demonstrates moderate antitrypanosomal activity against Trypanosoma brucei brucei with an IC50 less than 30,000 nM. Overall, m-Coumaric acid presents mixed efficacy across different biological activities, showing potential in specific applications such as HDAC inhibition, hemorrhage prevention, and as a herbicide, while displaying limited effects in other assays..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Turanose is a naturally occurring isomer of sucrose found in honey. It has anti-inflammatory and fat-regulating activities. It has research potential for obesity and related chronic diseases.

Chemical Properties

Molecular Weight	164.158
Formula	C₉H₈O₃
Cas No.	588-30-7
Smiles	O=C(O)C=CC=1C=CC=C(O)C1
Relative Density.	1.329g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 333.3 mg/mL (2030.36 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (12.18 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	6.0917 mL	30.4585 mL	60.9169 mL	304.5846 mL
5 mM	1.2183 mL	6.0917 mL	12.1834 mL	60.9169 mL
10 mM	0.6092 mL	3.0458 mL	6.0917 mL	30.4585 mL
20 mM	0.3046 mL	1.5229 mL	3.0458 mL	15.2292 mL
50 mM	0.1218 mL	0.6092 mL	1.2183 mL	6.0917 mL
100 mM	0.0609 mL	0.3046 mL	0.6092 mL	3.0458 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc