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Tetrabenazine

Name: Tetrabenazine
Brand: TargetMol
SKU: T0719
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0719Cas No. 58-46-8

Alias Xenazine, Ro 1-9569

Tetrabenazine (Ro 1-9569) is a former antipsychotic drug used to treat various movement disorders. It inhibits neurotransmitter uptake into adrenergic storage vesicles and serves as a high-affinity label for the vesicle transport system.

Tetrabenazine

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Purity: 99.91%

Catalog No. T0719Alias Xenazine, Ro 1-9569Cas No. 58-46-8

Pack Size	Price	Availability
25 mg	$30	In Stock
50 mg	$40	In Stock
100 mg	$60	In Stock
200 mg	$98	In Stock
500 mg	$196	In Stock
1 g	$298	In Stock
1 mL x 10 mM (in DMSO)	$44	In Stock

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Batch Information

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Purity:99.91%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Tetrabenazine (Ro 1-9569) is a former antipsychotic drug used to treat various movement disorders. It inhibits neurotransmitter uptake into adrenergic storage vesicles and serves as a high-affinity label for the vesicle transport system.
Synonyms	Xenazine, Ro 1-9569

Chemical Properties

Molecular Weight	317.42
Formula	C₁₉H₂₇NO₃
Cas No.	58-46-8
Smiles	O(C)C=1C=C2[C@]3(N(C[C@H](CC(C)C)C(=O)C3)CCC2=CC1OC)[H]
Relative Density.	1.12

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 18.33 mg/mL (57.76 mM), Sonication is recommended.

Ethanol: 32 mg/mL (100.81 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.3 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/Ethanol

	1mg	5mg	10mg	50mg
1 mM	3.1504 mL	15.7520 mL	31.5040 mL	157.5200 mL
5 mM	0.6301 mL	3.1504 mL	6.3008 mL	31.5040 mL
10 mM	0.3150 mL	1.5752 mL	3.1504 mL	15.7520 mL
20 mM	0.1575 mL	0.7876 mL	1.5752 mL	7.8760 mL
50 mM	0.0630 mL	0.3150 mL	0.6301 mL	3.1504 mL

Ethanol

	1mg	5mg	10mg	50mg
100 mM	0.0315 mL	0.1575 mL	0.3150 mL	1.5752 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc