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BMS-986121

Name: BMS-986121
Brand: TargetMol
SKU: T40392
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T40392Cas No. 313671-26-0

Alias BMS986121

BMS-986121 is a selective positive allosteric modulator (PAM) of the μ opioid receptor with analgesic effects.

BMS-986121

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Purity: 99.67%

Catalog No. T40392Alias BMS986121Cas No. 313671-26-0

BMS-986121 is a selective positive allosteric modulator (PAM) of the μ opioid receptor with analgesic effects.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$39	-	In Stock
5 mg	$89	-	In Stock
10 mg	$147	-	In Stock
25 mg	$297	-	In Stock
1 mL x 10 mM (in DMSO)	$98	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.67%

Appearance:Solid

Color:Yellow

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	BMS-986121 is a selective positive allosteric modulator (PAM) of the μ opioid receptor with analgesic effects.
In vitro	Method: In CHO-μ cells, BMS-986121 (1 μM–1 mM) was used to evaluate its effect on low-concentration endomorphin-I-induced β-arrestin recruitment and the enhancement of forskolin-stimulated adenylyl cyclase inhibition. At a concentration of 100 μM, its impact on the potency of endomorphin-I and leu-enkephalin in inhibiting cAMP accumulation was measured. Results: BMS-986121 significantly enhanced the β-arrestin recruitment and inhibitory effects of endomorphin-I. At 100 μM, BMS-986121 increased the potency of endomorphin-I and leu-enkephalin by approximately 4-fold and 6-fold, respectively.[1]
Synonyms	BMS986121

Chemical Properties

Molecular Weight	366.22
Formula	C₁₅H₉Cl₂N₃O₂S
Cas No.	313671-26-0
Smiles	O=[N+](C1=CC=C(C2=CSC(NC3=C(Cl)C=CC=C3Cl)=N2)C=C1)[O-]
Relative Density.	1.530 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (218.45 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7306 mL	13.6530 mL	27.3060 mL	136.5300 mL
5 mM	0.5461 mL	2.7306 mL	5.4612 mL	27.3060 mL
10 mM	0.2731 mL	1.3653 mL	2.7306 mL	13.6530 mL
20 mM	0.1365 mL	0.6826 mL	1.3653 mL	6.8265 mL
50 mM	0.0546 mL	0.2731 mL	0.5461 mL	2.7306 mL
100 mM	0.0273 mL	0.1365 mL	0.2731 mL	1.3653 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc