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BMS-986121

Name: BMS-986121
Brand: TargetMol
SKU: T40392
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T40392Cas No. 313671-26-0

Alias BMS986121

BMS-986121 is a selective positive allosteric modulator (PAM) of the μ opioid receptor with analgesic effects.

BMS-986121

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Purity: 99.67%

Catalog No. T40392Alias BMS986121Cas No. 313671-26-0

BMS-986121 is a selective positive allosteric modulator (PAM) of the μ opioid receptor with analgesic effects.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$39	-	In Stock
5 mg	$89	-	In Stock
10 mg	$147	-	In Stock
25 mg	$297	-	In Stock
1 mL x 10 mM (in DMSO)	$98	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.67%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	BMS-986121 is a selective positive allosteric modulator (PAM) of the μ opioid receptor with analgesic effects.
In vitro	Method: In CHO-μ cells, BMS-986121 (1 μM–1 mM) was used to evaluate its effect on low-concentration endomorphin-I-induced β-arrestin recruitment and the enhancement of forskolin-stimulated adenylyl cyclase inhibition. At a concentration of 100 μM, its impact on the potency of endomorphin-I and leu-enkephalin in inhibiting cAMP accumulation was measured. Results: BMS-986121 significantly enhanced the β-arrestin recruitment and inhibitory effects of endomorphin-I. At 100 μM, BMS-986121 increased the potency of endomorphin-I and leu-enkephalin by approximately 4-fold and 6-fold, respectively.[1]
Synonyms	BMS986121

Chemical Properties

Molecular Weight	366.22
Formula	C₁₅H₉Cl₂N₃O₂S
Cas No.	313671-26-0
Smiles	O=[N+](C1=CC=C(C2=CSC(NC3=C(Cl)C=CC=C3Cl)=N2)C=C1)[O-]
Relative Density.	1.530 g/cm3 (Predicted)
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (218.45 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7306 mL	13.6530 mL	27.3060 mL	136.5300 mL
5 mM	0.5461 mL	2.7306 mL	5.4612 mL	27.3060 mL
10 mM	0.2731 mL	1.3653 mL	2.7306 mL	13.6530 mL
20 mM	0.1365 mL	0.6826 mL	1.3653 mL	6.8265 mL
50 mM	0.0546 mL	0.2731 mL	0.5461 mL	2.7306 mL
100 mM	0.0273 mL	0.1365 mL	0.2731 mL	1.3653 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline /PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline /PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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Dose Conversion

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