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BMS-986121
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Catalog No. T40392Cas No. 313671-26-0
Alias BMS986121
BMS-986121 is a selective positive allosteric modulator (PAM) of the μ opioid receptor with analgesic effects.
BMS-986121
🥰Excellent
Purity: 99.67%
Catalog No. T40392Alias BMS986121Cas No. 313671-26-0
BMS-986121 is a selective positive allosteric modulator (PAM) of the μ opioid receptor with analgesic effects.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $55 | In Stock | |
| 5 mg | $126 | In Stock | |
| 10 mg | $183 | In Stock | |
| 25 mg | $297 | In Stock |
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Purity:99.67%
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Product Introduction
Bioactivity
Chemical Properties
| Description | BMS-986121 is a selective positive allosteric modulator (PAM) of the μ opioid receptor with analgesic effects. |
| In vitro | Method: In CHO-μ cells, BMS-986121 (1 μM–1 mM) was used to evaluate its effect on low-concentration endomorphin-I-induced β-arrestin recruitment and the enhancement of forskolin-stimulated adenylyl cyclase inhibition. At a concentration of 100 μM, its impact on the potency of endomorphin-I and leu-enkephalin in inhibiting cAMP accumulation was measured. Results: BMS-986121 significantly enhanced the β-arrestin recruitment and inhibitory effects of endomorphin-I. At 100 μM, BMS-986121 increased the potency of endomorphin-I and leu-enkephalin by approximately 4-fold and 6-fold, respectively.[1] |
| Synonyms | BMS986121 |
| Molecular Weight | 366.22 |
| Formula | C15H9Cl2N3O2S |
| Cas No. | 313671-26-0 |
| Smiles | O=[N+](C1=CC=C(C2=CSC(NC3=C(Cl)C=CC=C3Cl)=N2)C=C1)[O-] |
| Relative Density. | 1.530 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL (218.45 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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