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ZINC13000658
(Synonyms: ZINC1-3000658, ZINC1 3000658) Copy Product Info
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Synonyms: ZINC1-3000658, ZINC1 3000658
Catalog No. T212901 Copy Product Info
Purity: 99.74%
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ZINC13000658 is a METTL family inhibitor with significant anti-proliferative effects in various tumor cells, inducing G1 phase cell cycle arrest and apoptosis. Its IC50 values against HepG2 and SNU-449 cells are 5.632 μM and 6.184 μM respectively. Its mechanism of action may be related to inhibiting the activities of multiple methyltransferases such as METTL1/3/6/16/18, and it can be applied to basic research of various cancers.
Cas No. 1324070-76-9
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $113 | - | In Stock | |
| 5 mg | $249 | - | In Stock | |
| 10 mg | $398 | - | In Stock | |
| 25 mg | $796 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:99.74%
Appearance:Solid
Color:White
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | ZINC13000658 is a METTL family inhibitor with significant anti-proliferative effects in various tumor cells, inducing G1 phase cell cycle arrest and apoptosis. Its IC50 values against HepG2 and SNU-449 cells are 5.632 μM and 6.184 μM respectively. Its mechanism of action may be related to inhibiting the activities of multiple methyltransferases such as METTL1/3/6/16/18, and it can be applied to basic research of various cancers. |
| Targets & IC50 | SNU-449 cells:6.184 μM, HepG2 cells:5.632 μM |
| Synonyms | ZINC1-3000658, ZINC1 3000658 |
| Molecular Weight | 361.39 |
| Formula | C21H19N3O3 |
| Cas No. | 1324070-76-9 |
| Smiles | O=C1C=C(C(=O)NCCN2C=CC=3C=C(OC)C=CC32)C=4C=CC=CC4N1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Related Tags: ZINC13000658 chemical structure | ZINC13000658 formula | ZINC13000658 molecular weight
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