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PTP1B-IN-4

Name: PTP1B-IN-4
Brand: TargetMol
SKU: T24073
Rating: 4.5 (1 reviews)

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Catalog No. T24073Cas No. 765317-72-4

Alias PTP1B-inhibitor-4, PTP1B-inhibitor-2, PTP1B-IN-2, PTP1BIN2, PTP1B inhibitor 4, PTP1B inhibitor 2, PTP1B IN 2, NUN-17724, NUN17724, NUN 17724, FRJ

PTP1B-IN-4 (NUN-17724) is an allosteric PTP1B inhibitor with an IC50 of 8 μM. PTP1B-IN-4 can be used in studies about obesity and diabetes.

PTP1B-IN-4

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Catalog No. T24073Alias PTP1B-inhibitor-4, PTP1B-inhibitor-2, PTP1B-IN-2, PTP1BIN2, PTP1B inhibitor 4, PTP1B inhibitor 2, PTP1B IN 2, NUN-17724, NUN17724, NUN 17724, FRJCas No. 765317-72-4

PTP1B-IN-4 (NUN-17724) is an allosteric PTP1B inhibitor with an IC50 of 8 μM. PTP1B-IN-4 can be used in studies about obesity and diabetes.

Pack Size	Price	USA Warehouse	Global Warehouse
500 μg	$218	35 days	35 days
1 mg	$397	35 days	35 days
5 mg	$957	35 days	35 days
10 mg	$1,690	35 days	35 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	PTP1B-IN-4 (NUN-17724) is an allosteric PTP1B inhibitor with an IC50 of 8 μM. PTP1B-IN-4 can be used in studies about obesity and diabetes.
Targets&IC50	PTP1B:8 μM (IC50)
In vitro	In CHO cells overexpressing human IR, PTP1B-IN-4 (250 µM) stimulates the phosphorylation of insulin receptors. PTP1B-IN-4 induces phosphorylation of IRS-1 and Akt which are proteins downstream of the insulin receptor[3].
Synonyms	PTP1B-inhibitor-4, PTP1B-inhibitor-2, PTP1B-IN-2, PTP1BIN2, PTP1B inhibitor 4, PTP1B inhibitor 2, PTP1B IN 2, NUN-17724, NUN17724, NUN 17724, FRJ

Chemical Properties

Molecular Weight	741.45
Formula	C₂₆H₁₉Br₂N₃O₇S₃
Cas No.	765317-72-4
Smiles	C(=O)(C=1C=2C(OC1CC)=CC(S(NC3=CC=C(S(NC4=NC=CS4)(=O)=O)C=C3)(=O)=O)=CC2)C5=CC(Br)=C(O)C(Br)=C5
Relative Density.	1.812 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90 mg/mL (121.38 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 3.3 mg/mL (4.45 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.3487 mL	6.7435 mL	13.4871 mL	67.4354 mL
5 mM	0.2697 mL	1.3487 mL	2.6974 mL	13.4871 mL
10 mM	0.1349 mL	0.6744 mL	1.3487 mL	6.7435 mL
20 mM	0.0674 mL	0.3372 mL	0.6744 mL	3.3718 mL
50 mM	0.0270 mL	0.1349 mL	0.2697 mL	1.3487 mL
100 mM	0.0135 mL	0.0674 mL	0.1349 mL	0.6744 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc