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PTP1B-IN-4

Name: PTP1B-IN-4
Brand: TargetMol
SKU: T24073
Rating: 4.5 (1 reviews)

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Catalog No. T24073Cas No. 765317-72-4

Alias PTP1B-inhibitor-4, PTP1B-inhibitor-2, PTP1B-IN-2, PTP1BIN2, PTP1B inhibitor 4, PTP1B inhibitor 2, PTP1B IN 2, NUN-17724, NUN17724, NUN 17724, FRJ

PTP1B-IN-4 (NUN-17724) is an allosteric PTP1B inhibitor with an IC50 of 8 μM. PTP1B-IN-4 can be used in studies about obesity and diabetes.

PTP1B-IN-4

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Catalog No. T24073Alias PTP1B-inhibitor-4, PTP1B-inhibitor-2, PTP1B-IN-2, PTP1BIN2, PTP1B inhibitor 4, PTP1B inhibitor 2, PTP1B IN 2, NUN-17724, NUN17724, NUN 17724, FRJCas No. 765317-72-4

PTP1B-IN-4 (NUN-17724) is an allosteric PTP1B inhibitor with an IC50 of 8 μM. PTP1B-IN-4 can be used in studies about obesity and diabetes.

Pack Size	Price	Availability
500 μg	$218	35 days
1 mg	$397	35 days
5 mg	$957	35 days
10 mg	$1,690	35 days

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Product Introduction

Bioactivity

Description	PTP1B-IN-4 (NUN-17724) is an allosteric PTP1B inhibitor with an IC50 of 8 μM. PTP1B-IN-4 can be used in studies about obesity and diabetes.
Targets&IC50	PTP1B:8 μM (IC50)
In vitro	In CHO cells overexpressing human IR, PTP1B-IN-4 (250 µM) stimulates the phosphorylation of insulin receptors. PTP1B-IN-4 induces phosphorylation of IRS-1 and Akt which are proteins downstream of the insulin receptor[3].
Synonyms	PTP1B-inhibitor-4, PTP1B-inhibitor-2, PTP1B-IN-2, PTP1BIN2, PTP1B inhibitor 4, PTP1B inhibitor 2, PTP1B IN 2, NUN-17724, NUN17724, NUN 17724, FRJ

Chemical Properties

Molecular Weight	741.45
Formula	C₂₆H₁₉Br₂N₃O₇S₃
Cas No.	765317-72-4
Relative Density.	1.812 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90 mg/mL (121.4 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.3487 mL	6.7435 mL	13.4871 mL	67.4354 mL
5 mM	0.2697 mL	1.3487 mL	2.6974 mL	13.4871 mL
10 mM	0.1349 mL	0.6744 mL	1.3487 mL	6.7435 mL
20 mM	0.0674 mL	0.3372 mL	0.6744 mL	3.3718 mL
50 mM	0.0270 mL	0.1349 mL	0.2697 mL	1.3487 mL
100 mM	0.0135 mL	0.0674 mL	0.1349 mL	0.6744 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc