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A-317491 sodium salt hydrate

Name: A-317491 sodium salt hydrate
Brand: TargetMol
SKU: T10204
Rating: 4.5 (1 reviews)

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Catalog No. T10204

Alias A-317491 sodium salt hydrate (475205-49-3 free base)

A-317491 sodium salt hydrate is a non-nucleotide P2X3 and P2X2/3 receptor antagonist that inhibits receptor-mediated calcium flux.

A-317491 sodium salt hydrate

Copy Product Info

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Catalog No. T10204Alias A-317491 sodium salt hydrate (475205-49-3 free base)

A-317491 sodium salt hydrate is a non-nucleotide P2X3 and P2X2/3 receptor antagonist that inhibits receptor-mediated calcium flux.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$1,520	4-6 weeks	4-6 weeks
50 mg	$1,980	4-6 weeks	4-6 weeks
100 mg	$2,500	4-6 weeks	4-6 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	A-317491 sodium salt hydrate is a non-nucleotide P2X3 and P2X2/3 receptor antagonist that inhibits receptor-mediated calcium flux.
In vitro	A-317491 is known that P2X3 and P2X2/3 receptors stimulate the pronociceptive effects of ATP upon activation. Studies indicate that the P2X3 receptor is implicated in both neuropathic and inflammatory pain. The P2X3 receptor is a promising target for therapeutic intervention in cancer patients for pain management.
Synonyms	A-317491 sodium salt hydrate (475205-49-3 free base)

Chemical Properties

Molecular Weight	606.57
Formula	C₃₃H₂₉NNaO₉
Smiles	O=C(O)C1=CC(C(N([C@H]2CCCC3=C2C=CC=C3)CC4=CC=CC(OC5=CC=CC=C5)=C4)=O)=C(C=C1C(O)=O)C(O)=O.[Na+].O
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (164.86 mM), Sonication is recommended.

H2O: 100 mg/mL (164.86 mM), Sonication is recommended.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	1.6486 mL	8.2431 mL	16.4861 mL	82.4307 mL
5 mM	0.3297 mL	1.6486 mL	3.2972 mL	16.4861 mL
10 mM	0.1649 mL	0.8243 mL	1.6486 mL	8.2431 mL
20 mM	0.0824 mL	0.4122 mL	0.8243 mL	4.1215 mL
50 mM	0.0330 mL	0.1649 mL	0.3297 mL	1.6486 mL
100 mM	0.0165 mL	0.0824 mL	0.1649 mL	0.8243 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc