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Pactimibe sulfate

Name: Pactimibe sulfate
Brand: TargetMol
SKU: T62974
Price: 133 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: CS-505, CS 505) Copy Product Info

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Synonyms: CS-505, CS 505

Catalog No. T62974 Copy Product Info

Purity: 99.08%

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Pactimibe sulfate (CS-505) is a dual ACAT1/2 inhibitor that targets ACAT1 with an IC50 value of 4.9 μM and ACAT2 with an IC50 value of 3.0 μM. Pactimibe sulfate (CS-505) inhibits oleoyl-CoA noncompetitively with a Ki value of 5.6 μM and significantly suppresses cholesterol ester formation with an IC50 value of 6.7 μM. Pactimibe sulfate (CS-505) reduces plasma cholesterol activity and demonstrates anti-atherogenic potential. Pactimibe sulfate (CS-505) is applicable to lipid metabolism, atherosclerosis, and cholesterol homeostasis-related research.

Cas No. 608510-47-0

Pack Size	Price	USA Stock	Global Stock
1 mg	$133	-	In Stock
5 mg	$333	-	In Stock
10 mg	$596	-	In Stock
25 mg	$1,230	-	In Stock
50 mg	$1,880	-	In Stock
1 mL x 10 mM (in DMSO)	$342	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.08%

Appearance:Solid

Color:Purple

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Pactimibe sulfate (CS-505) is a dual ACAT1/2 inhibitor that targets ACAT1 with an IC50 value of 4.9 μM and ACAT2 with an IC50 value of 3.0 μM. Pactimibe sulfate (CS-505) inhibits oleoyl-CoA noncompetitively with a Ki value of 5.6 μM and significantly suppresses cholesterol ester formation with an IC50 value of 6.7 μM. Pactimibe sulfate (CS-505) reduces plasma cholesterol activity and demonstrates anti-atherogenic potential. Pactimibe sulfate (CS-505) is applicable to lipid metabolism, atherosclerosis, and cholesterol homeostasis-related research.
Targets & IC50	ACAT2:3.0 μM, ACAT1:4.9 μM, ACAT:4.7 μM (in THP-1 cells), cholesteryl ester formation:6.7 μM, ACAT:2.7 μM (in macrophages), ACAT:2 μM (in the liver), oleoyl-CoA:5.6 μM (Ki)
In vitro	Pactimibe sulfate (CS-505) inhibits ACAT activities in the liver, macrophages and THP-1 cells with IC50 values of 2 μM, 2.7 μM and 4.7 μM, respectively[1]. Pactimibe sulfate (CS-505) inhibits ACAT1 and ACAT2 activities with IC50 values of 4.9 μM and 3 μM[1].
In vivo	Pactimibe sulfate (CS-505) (diet supplemented with 0.03 or 0.1% (w/w); 12-24weeks) significantly increases plasma triglyceride (TG) and reduces non-high density lipoprotein cholesterol (non-HDL-C) in Male apoE−/− mice[1]. Pactimibe sulfate (CS-505) (diet supplemented with 0.03 or 0.1% (w/w); 12-24weeks) reduces MMP-2 expression by 44 and 70% in Male apoE−/− mice[1].
Synonyms	CS-505, CS 505

Chemical Properties

Molecular Weight	931.27
Formula	C₅₀H₈₂N₄O₁₀S
Cas No.	608510-47-0
Smiles	O=C(CC1=C(C)C(CCN2CCCCCCCC)=C2C(NC(C(C)(C)C)=O)=C1C)O.O=S(O)(O)=O.O=C(CC3=C(C)C(CCN4CCCCCCCC)=C4C(NC(C(C)(C)C)=O)=C3C)O

Storage & Solubility Information

Storage

Keep away from moisture, Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 96 mg/mL (103.09 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.0738 mL	5.3690 mL	10.7380 mL	53.6901 mL
5 mM	0.2148 mL	1.0738 mL	2.1476 mL	10.7380 mL
10 mM	0.1074 mL	0.5369 mL	1.0738 mL	5.3690 mL
20 mM	0.0537 mL	0.2685 mL	0.5369 mL	2.6845 mL
50 mM	0.0215 mL	0.1074 mL	0.2148 mL	1.0738 mL
100 mM	0.0107 mL	0.0537 mL	0.1074 mL	0.5369 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Related Tags: Pactimibe sulfate chemical structure | Pactimibe sulfate in vivo | Pactimibe sulfate in vitro | Pactimibe sulfate formula | Pactimibe sulfate molecular weight