PCSK9 Protein, Mouse, Recombinant (His)

Name: PCSK9 Protein, Mouse, Recombinant (His)
Brand: TargetMol
SKU: TMPY-01245
Price: 63 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: proprotein convertase subtilisin/kexin type 9, PC9, Narc1, HCHOLA3, FH3, AI747682, AI415265) Copy Product Info

Synonyms: proprotein convertase subtilisin/kexin type 9, PC9, Narc1, HCHOLA3, FH3, AI747682, AI415265

Catalog No. TMPY-01245 Copy Product Info

PCSK9 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 72.6 kDa and the accession number is Q80W65.

Pack Size	Price	USA Stock	Global Stock
5 µg	$63	-	In Stock
10 µg	$98	-	In Stock
20 µg	$165	7-10 days	7-10 days
50 µg	$342	7-10 days	7-10 days
100 µg	$696	-	In Stock
200 µg	$1,060	7-10 days	7-10 days
500 µg	$2,230	7-10 days	7-10 days
1 mg	$4,530	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:> 95 % as determined by SDS-PAGE

Appearance:Lyophilized powder

Color:White

Resource Download

COA User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	Measured by its binding ability in a functional ELISA. Immobilized mouse PCSK9 at 10 μg/ml (100 μl/well) can bind biotinylated recombinant human LDLR. The EC50 of biotinylated human LDLR is 0.12 μg/ml.
Description	PCSK9 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 72.6 kDa and the accession number is Q80W65.
Species	Mouse
Expression System	HEK293 Cells
Tag	C-His
Accession Number	Q80W65
Construction	A DNA sequence encoding the full length of mouse PCSK9 (NP_705793.1) precursor (Met 1-Gln 694) was expressed, with a C-terminal polyhistidine tag. Predicted N terminal: Gln 35
Protein Purity	> 95 % as determined by SDS-PAGE
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Supplied as sterile 15 mM Tris, 90 mM NaCl, 50% Glycerol, pH 7.5.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Synonyms	proprotein convertase subtilisin/kexin type 9, PC9, Narc1, HCHOLA3, FH3, AI747682, AI415265
Research Background	Proprotein convertase subtilisin/kexin type 9 (PCSK9), also known as NARC1 (neural apoptosis regulated convertase), which is a newly identified human secretory subtilase belonging to the proteinase K subfamily of the secretory subtilase family. PCSK9 protein is an enzyme which in humans is encoded by the PCSK9 gene with orthologs found across many species. It is expressed in neuroepithelioma, colon carcinoma, hepatic and pancreatic cell lines, and in Schwann cells. PCSK9 protein is highly expressed in the liver and regulates low density lipoprotein receptor (LDLR) protein levels. Inhibition of PCSK9 protein function is currently being explored as a means of lowering cholesterol levels. Thereby, PCSK9 protein is regarded as a new strategy to treat hypercholesterolemia. PCSK9 protein contributes to cholesterol homeostasis and may have a role in the differentiation of cortical neurons.

Chemical Properties

Molecular Weight

72.6 kDa (predicted); 19 & 65 kDa (reducing condition, due to glycosylation)

Storage & Solubility Information

Shipping	Proteins are shipped with blue ice.
Storage	It is recommended to store the product under sterile conditions at -20°C to -80°C. Samples are stable for up to 12 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.