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Chlorzoxazone

Name: Chlorzoxazone
Brand: TargetMol
SKU: T1650
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1650Cas No. 95-25-0

Alias Paraflex, Chlorzoxazon

Chlorzoxazone (Chlorzoxazon) is a Muscle Relaxant. The physiologic effect of chlorzoxazone is by means of Centrally-mediated Muscle Relaxation.

Chlorzoxazone

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Purity: 99.6%

Catalog No. T1650Alias Paraflex, ChlorzoxazonCas No. 95-25-0

Chlorzoxazone (Chlorzoxazon) is a Muscle Relaxant. The physiologic effect of chlorzoxazone is by means of Centrally-mediated Muscle Relaxation.

Pack Size	Price	USA Warehouse	Global Warehouse
1 g	$30	In Stock	In Stock
5 g	$48	-	In Stock
10 g	$68	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.6%

Appearance:Solid

Color:White

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	Chlorzoxazone (Chlorzoxazon) is a Muscle Relaxant. The physiologic effect of chlorzoxazone is by means of Centrally-mediated Muscle Relaxation.
In vivo	Chlorzoxazone is a central acting skeletal muscle relaxant that operates by suppressing reflex actions in the spinal column. It is capable of activating rat brain SK2 channel currents within cells. Metabolically, Chlorzoxazone is primarily transformed by CYP2E1 into 6-hydroxychlorzoxazone. Other human liver cytochrome P450 enzymes, such as CYP1A1, CYP1A2, and CYP3A4, may also contribute to its metabolism.
Synonyms	Paraflex, Chlorzoxazon

Chemical Properties

Molecular Weight	169.57
Formula	C₇H₄ClNO₂
Cas No.	95-25-0
Smiles	ClC1=CC=C2OC(=O)NC2=C1
Relative Density.	1.486 g/cm3

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 32 mg/mL (188.71 mM), Sonication is recommended.

DMSO: 45 mg/mL (265.38 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (11.79 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	5.8973 mL	29.4863 mL	58.9727 mL	294.8635 mL
5 mM	1.1795 mL	5.8973 mL	11.7945 mL	58.9727 mL
10 mM	0.5897 mL	2.9486 mL	5.8973 mL	29.4863 mL
20 mM	0.2949 mL	1.4743 mL	2.9486 mL	14.7432 mL
50 mM	0.1179 mL	0.5897 mL	1.1795 mL	5.8973 mL
100 mM	0.0590 mL	0.2949 mL	0.5897 mL	2.9486 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc