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Chlorzoxazone

Name: Chlorzoxazone
Brand: TargetMol
SKU: T1650
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1650Cas No. 95-25-0

Alias Paraflex, Chlorzoxazon

Chlorzoxazone (Chlorzoxazon) is a Muscle Relaxant. The physiologic effect of chlorzoxazone is by means of Centrally-mediated Muscle Relaxation.

Chlorzoxazone

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Purity: 99.6%

Catalog No. T1650Alias Paraflex, ChlorzoxazonCas No. 95-25-0

Chlorzoxazone (Chlorzoxazon) is a Muscle Relaxant. The physiologic effect of chlorzoxazone is by means of Centrally-mediated Muscle Relaxation.

Pack Size	Price	Availability
1 g	$30	In Stock
5 g	$48	In Stock
10 g	$68	In Stock

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Purity:99.6%

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COA HNMR HPLC

Product Introduction

Bioactivity

Description	Chlorzoxazone (Chlorzoxazon) is a Muscle Relaxant. The physiologic effect of chlorzoxazone is by means of Centrally-mediated Muscle Relaxation.
In vivo	Chlorzoxazone is a central acting skeletal muscle relaxant that operates by suppressing reflex actions in the spinal column. It is capable of activating rat brain SK2 channel currents within cells. Metabolically, Chlorzoxazone is primarily transformed by CYP2E1 into 6-hydroxychlorzoxazone. Other human liver cytochrome P450 enzymes, such as CYP1A1, CYP1A2, and CYP3A4, may also contribute to its metabolism.
Synonyms	Paraflex, Chlorzoxazon

Chemical Properties

Molecular Weight	169.57
Formula	C₇H₄ClNO₂
Cas No.	95-25-0
Smiles	ClC1=CC=C2OC(=O)NC2=C1
Relative Density.	1.486 g/cm3
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 32 mg/mL (188.71 mM), Sonication is recommended.

DMSO: 45 mg/mL (265.38 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (11.79 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	5.8973 mL	29.4863 mL	58.9727 mL	294.8635 mL
5 mM	1.1795 mL	5.8973 mL	11.7945 mL	58.9727 mL
10 mM	0.5897 mL	2.9486 mL	5.8973 mL	29.4863 mL
20 mM	0.2949 mL	1.4743 mL	2.9486 mL	14.7432 mL
50 mM	0.1179 mL	0.5897 mL	1.1795 mL	5.8973 mL
100 mM	0.0590 mL	0.2949 mL	0.5897 mL	2.9486 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc