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Anti-Phospho-RCC1 (Ser11) Polyclonal Antibody 2
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Catalog No. TMAB-11234
Anti-Phospho-RCC1 (Ser11) Polyclonal Antibody 2 is a Rabbit antibody targeting Phospho-RCC1 (Ser11). Anti-Phospho-RCC1 (Ser11) Polyclonal Antibody 2 can be used in WB.
Anti-Phospho-RCC1 (Ser11) Polyclonal Antibody 2
Anti-Phospho-RCC1 (Ser11) Polyclonal Antibody 2
😃Good
Catalog No. TMAB-11234
Anti-Phospho-RCC1 (Ser11) Polyclonal Antibody 2 is a Rabbit antibody targeting Phospho-RCC1 (Ser11). Anti-Phospho-RCC1 (Ser11) Polyclonal Antibody 2 can be used in WB.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $220 | 7-10 days | 7-10 days | |
| 100 μL | $371 | 7-10 days | 7-10 days | |
| 200 μL | $529 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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| Description | Anti-Phospho-RCC1 (Ser11) Polyclonal Antibody 2 is a Rabbit antibody targeting Phospho-RCC1 (Ser11). Anti-Phospho-RCC1 (Ser11) Polyclonal Antibody 2 can be used in WB. |
| Ig Type | IgG |
| Reactivity | Human (predicted:Mouse,Rat,Dog,Pig,Cow,Horse,Sheep) |
| Application | |
| Recommended Dose | WB: 1:500-2000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Nucleus. Cytoplasm. Note=Becomes dispersed throughout the cytoplasm during mitosis. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | Ran GTPase plays important roles in nucleocytoplasmic transport in interphase and in both spindle formation and nuclear envelope (NE) assembly during mitosis. The latter functions rely on the presence of high local concentrations of GTP bound Ran near mitotic chromatin. RanGTP localization has been proposed to result from the association of Ran's GDP/GTP exchange factor, RCC1, with chromatin , but Ran is shown here to bind directly to chromatin in two modes, either dependent or independent of RCC1, and, where bound, to increase the affinity of chromatin for NE membranes. |
| Immunogen | KLH conjugated Synthesised phosphopeptide: human RCC1 around the phosphorylation site of Ser11 |
| Antigen Species | Human |
| Gene Name | RCC1 |
| Gene ID | |
| Protein Name | Regulator of chromosome condensation |
| Uniprot ID | |
| Function | Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP. Involved in the regulation of onset of chromosome condensation in the S phase. Binds both to the nucleosomes and double-stranded DNA. RCC1-Ran complex (together with other proteins) acts as a component of a signal transmission pathway that detects unreplicated DNA. Plays a key role in nucleo-cytoplasmic transport, mitosis and nuclear-envelope assembly. |
| Molecular Weight | Theoretical: 45 kDa. |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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