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8-CPT-Cyclic AMP sodium

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Catalog No. T21705Cas No. 93882-12-3
Alias 8-CPT-Cyclic AMP (sodium salt), 8-CPT-cAMP sodium, 8-(p-Chlorophenylthio)-cAMP sodium

8-CPT-Cyclic AMP sodium is an activator of cAMP-dependent PKA and cAMP receptor activator, and also an inhibitor of cAMP-specific phosphodiesterase (PDE VA) (IC50 = 0.9 μM). The IC50 values for PDE III and PDE IV are 24 and 25 μM, respectively.

8-CPT-Cyclic AMP sodium

8-CPT-Cyclic AMP sodium

😃Good
Catalog No. T21705Alias 8-CPT-Cyclic AMP (sodium salt), 8-CPT-cAMP sodium, 8-(p-Chlorophenylthio)-cAMP sodiumCas No. 93882-12-3
8-CPT-Cyclic AMP sodium is an activator of cAMP-dependent PKA and cAMP receptor activator, and also an inhibitor of cAMP-specific phosphodiesterase (PDE VA) (IC50 = 0.9 μM). The IC50 values for PDE III and PDE IV are 24 and 25 μM, respectively.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
2 mg$3535 days35 days
5 mg$5335 days35 days
10 mg$7435 days35 days
25 mg$13835 days35 days
50 mg$25935 days35 days
1 mL x 10 mM (in DMSO)$6635 days35 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
8-CPT-Cyclic AMP sodium is an activator of cAMP-dependent PKA and cAMP receptor activator, and also an inhibitor of cAMP-specific phosphodiesterase (PDE VA) (IC50 = 0.9 μM). The IC50 values for PDE III and PDE IV are 24 and 25 μM, respectively.
Targets&IC50
PDE5A:0.9 μM, PDE4:25 μM, PDE3:24 μM
In vitro
α-Fas and TNF-α/CHX can induce neutrophil death within 2 hours, with a mortality rate exceeding 90%. while 8-CPT-Cyclic AMP sodium (0.7 mM) delays TNF-α/CHX- or a-Fas-induced apoptosis, with a stronger inhibitory effect on TNF-α/CHX-induced apoptosis than on a-Fas-induced apoptosis [2].
Synonyms8-CPT-Cyclic AMP (sodium salt), 8-CPT-cAMP sodium, 8-(p-Chlorophenylthio)-cAMP sodium
Chemical Properties
Molecular Weight493.79
FormulaC16H14ClN5NaO6PS
Cas No.93882-12-3
SmilesNC1=C2C(N([C@@H]3O[C@@]4([H])[C@](OP([O-])(OC4)=O)([H])[C@H]3O)C(SC5=CC=C(C=C5)Cl)=N2)=NC=N1.[Na+]
Relative Density.no data available
ColorYellow
AppearanceSolid
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 45 mg/mL (91.13 mM), Sonication is recommended.
H2O: 40 mg/mL (81.01 mM), Sonication is recommended.
Solution Preparation Table
H2O/DMSO
1mg5mg10mg50mg
1 mM2.0252 mL10.1258 mL20.2515 mL101.2576 mL
5 mM0.4050 mL2.0252 mL4.0503 mL20.2515 mL
10 mM0.2025 mL1.0126 mL2.0252 mL10.1258 mL
20 mM0.1013 mL0.5063 mL1.0126 mL5.0629 mL
50 mM0.0405 mL0.2025 mL0.4050 mL2.0252 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Stock solution preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (stock solution concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
The above example illustrates how to use "In Vivo Formulation Calculator" and does not represent a recommended formulation for any specific compound. Please select an appropriate dissolution method based on your experimental animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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%
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Keywords

8CPTCyclic AMP (sodium salt)8-CPT-Cyclic AMP8 CPT Cyclic AMP (sodium salt)
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