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8-CPT-Cyclic AMP (sodium salt)

Catalog No. T21705 CAS 93882-12-3

8-CPT-Cyclic AMP (8-CPT-cAMP) sodium functions dually as a selective activator of cyclic AMP-dependent protein kinase (PKA) and as a potent inhibitor of the cyclic GMP-specific phosphodiesterase (PDE VA), demonstrating an inhibitory concentration (IC 50) of 0.9 μM. Additionally, this compound inhibits PDE III and PDE IV, while significantly activating Epac, showcasing its diverse pharmacological activities [1] [2].

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8-CPT-Cyclic AMP (sodium salt) Chemical Structure

8-CPT-Cyclic AMP (sodium salt), CAS 93882-12-3

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Biological Description

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Description

In vitro

a-Fas and TNF-α/CHX induces neutrophil death rapidly (within 2 h) to at least 90%. The commonly used cAMP analog 8-pCPT-cAMP (0.7 mM) delays TNF- /CHX-induced and a-Fas-induced apoptosis. It is more efficient against TNF- /CHX-induced apoptosis than against a-Fas [2].

Molecular Weight	493.79
Formula	C16H14ClN5NaO6PS
CAS No.	93882-12-3

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Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

8-CPT-Cyclic AMP (sodium salt) 93882-12-3 8CPTCyclic AMP (sodium salt) 8 CPT Cyclic AMP (sodium salt) 8-CPT-Cyclic AMP inhibitor inhibit

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