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8-CPT-Cyclic AMP sodium

Name: 8-CPT-Cyclic AMP sodium
Brand: TargetMol
SKU: T21705
Rating: 4.5 (1 reviews)

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Catalog No. T21705Cas No. 93882-12-3

Alias 8-CPT-Cyclic AMP (sodium salt), 8-CPT-cAMP sodium, 8-(p-Chlorophenylthio)-cAMP sodium

8-CPT-Cyclic AMP sodium is an activator of cAMP-dependent PKA and cAMP receptor activator, and also an inhibitor of cAMP-specific phosphodiesterase (PDE VA) (IC50 = 0.9 μM). The IC50 values for PDE III and PDE IV are 24 and 25 μM, respectively.

8-CPT-Cyclic AMP sodium

😃Good

Catalog No. T21705Alias 8-CPT-Cyclic AMP (sodium salt), 8-CPT-cAMP sodium, 8-(p-Chlorophenylthio)-cAMP sodiumCas No. 93882-12-3

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$35	35 days	35 days
5 mg	$53	35 days	35 days
10 mg	$74	35 days	35 days
25 mg	$138	35 days	35 days
50 mg	$259	35 days	35 days
1 mL x 10 mM (in DMSO)	$66	35 days	35 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	8-CPT-Cyclic AMP sodium is an activator of cAMP-dependent PKA and cAMP receptor activator, and also an inhibitor of cAMP-specific phosphodiesterase (PDE VA) (IC50 = 0.9 μM). The IC50 values for PDE III and PDE IV are 24 and 25 μM, respectively.
Targets&IC50	PDE5A:0.9 μM, PDE4:25 μM, PDE3:24 μM
In vitro	α-Fas and TNF-α/CHX can induce neutrophil death within 2 hours, with a mortality rate exceeding 90%. while 8-CPT-Cyclic AMP sodium (0.7 mM) delays TNF-α/CHX- or a-Fas-induced apoptosis, with a stronger inhibitory effect on TNF-α/CHX-induced apoptosis than on a-Fas-induced apoptosis [2].
Synonyms	8-CPT-Cyclic AMP (sodium salt), 8-CPT-cAMP sodium, 8-(p-Chlorophenylthio)-cAMP sodium

Chemical Properties

Molecular Weight	493.79
Formula	C₁₆H₁₄ClN₅NaO₆PS
Cas No.	93882-12-3
Smiles	NC1=C2C(N([C@@H]3O[C@@]4([H])[C@](OP([O-])(OC4)=O)([H])[C@H]3O)C(SC5=CC=C(C=C5)Cl)=N2)=NC=N1.[Na+]
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (91.13 mM), Sonication is recommended.

H2O: 40 mg/mL (81.01 mM), Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0252 mL	10.1258 mL	20.2515 mL	101.2576 mL
5 mM	0.4050 mL	2.0252 mL	4.0503 mL	20.2515 mL
10 mM	0.2025 mL	1.0126 mL	2.0252 mL	10.1258 mL
20 mM	0.1013 mL	0.5063 mL	1.0126 mL	5.0629 mL
50 mM	0.0405 mL	0.2025 mL	0.4050 mL	2.0252 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc