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GSK5182

Name: GSK5182
Brand: TargetMol
SKU: T8370
Price: 48 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T8370Cas No. 877387-37-6

GSK5182 is a highly selective inverse estrogen-related receptor γ agonist (IC50 : 79 nM)

GSK5182

🥰Excellent

Purity: 99.42%

Catalog No. T8370Cas No. 877387-37-6

GSK5182 is a highly selective inverse estrogen-related receptor γ agonist (IC50 : 79 nM)

Pack Size	Price	Availability
1 mg	$48	In Stock
2 mg	$68	In Stock
5 mg	$97	In Stock
10 mg	$155	In Stock
25 mg	$289	In Stock
50 mg	$438	In Stock
100 mg	$647	In Stock
1 mL x 10 mM (in DMSO)	$116	In Stock

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Batch Information

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Purity:99.42%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	GSK5182 is a highly selective inverse estrogen-related receptor γ agonist (IC50 : 79 nM)
Targets&IC50	ERRγ:79 nM (IC50)
In vitro	Small interfering RNA (siRNA)-mediated knockdown of ERRγ (siRNA-ERRγ) or an ERRγ inverse agonist, GSK5182, were also used to examine the effects of ERRγ inhibition on the proliferation and growth of a human hepatoma cell line, PLC/PRF/5[1].
In vivo	a hyperinsulinemic-euglycemic clamp study and long-term studies of the antidiabetic effects of GSK5182, the ERRγ-specific inverse agonist, in db/db and DIO mice demonstrated that GSK5182 normalizes hyperglycemia mainly through inhibition of hepatic glucose production[2].
Cell Research	Cell Line:The human hepatoma cell line PLC/PRF/5. Concentration:0 μM, 10 μM, 20 μM. Incubation Time:0 hour, 24 hours, 48 hours, 72 hours

Chemical Properties

Molecular Weight	417.54
Formula	C₂₇H₃₁NO₃
Cas No.	877387-37-6
Smiles	C(=C(/CCCO)\C1=CC=CC=C1)(\C2=CC=C(OCCN(C)C)C=C2)/C3=CC=C(O)C=C3
Relative Density.	1.132 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

keep away from direct sunlight,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (143.7 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3950 mL	11.9749 mL	23.9498 mL	119.7490 mL
5 mM	0.4790 mL	2.3950 mL	4.7900 mL	23.9498 mL
10 mM	0.2395 mL	1.1975 mL	2.3950 mL	11.9749 mL
20 mM	0.1197 mL	0.5987 mL	1.1975 mL	5.9875 mL
50 mM	0.0479 mL	0.2395 mL	0.4790 mL	2.3950 mL
100 mM	0.0239 mL	0.1197 mL	0.2395 mL	1.1975 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc