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KB-5492 free base

Name: KB-5492 free base
Brand: TargetMol
SKU: T62396
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T62396Cas No. 113594-64-2

KB-5492 free base is an orally available and selective antiulcer agent that inhibits sigma receptors, inhibits [3H]1,3-di(2-tolyl)guanidine (DTG) binding to sigma receptors, and may be useful in the study of gastric lesions and gastric secretion.

KB-5492 free base

🥰Excellent

Purity: 97.94%

Catalog No. T62396Cas No. 113594-64-2

Pack Size	Price	Availability
2 mg	$35	In Stock
5 mg	$56	In Stock
10 mg	$79	In Stock
25 mg	$128	In Stock
50 mg	$187	In Stock
100 mg	$276	In Stock
500 mg	$682	In Stock
1 mL x 10 mM (in DMSO)	$62	In Stock

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Bulk & Custom

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:97.94%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	KB-5492 free base is an orally available and selective antiulcer agent that inhibits sigma receptors, inhibits [3H]1,3-di(2-tolyl)guanidine (DTG) binding to sigma receptors, and may be useful in the study of gastric lesions and gastric secretion.
Targets&IC50	σ receptor (DTG site):3.15 μM
In vitro	KB-5492 free base selectively inhibited specific [3H]1,3-di(2-tolyl)guanidine (DTG) binding to the sigma receptor (IC50 = 3.15 microM) with a pseudo-Hill coefficient of 0.33[1].
In vivo	In male Sprague-Dawley rats weighing 210-240 g, induction of gastric mucosal damage was reduced by KB-5492 free base (200 mg/kg; oral gavage) compared to the control group. Additionally, it prevented deep mucosal lesions and exfoliation of surface epithelial cells[2].

Chemical Properties

Molecular Weight	430.49
Formula	C₂₃H₃₀N₂O₆
Cas No.	113594-64-2
Smiles	COc1ccc(OC(=O)CN2CCN(Cc3cc(OC)c(OC)c(OC)c3)CC2)cc1

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (185.83 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3229 mL	11.6147 mL	23.2293 mL	116.1467 mL
5 mM	0.4646 mL	2.3229 mL	4.6459 mL	23.2293 mL
10 mM	0.2323 mL	1.1615 mL	2.3229 mL	11.6147 mL
20 mM	0.1161 mL	0.5807 mL	1.1615 mL	5.8073 mL
50 mM	0.0465 mL	0.2323 mL	0.4646 mL	2.3229 mL
100 mM	0.0232 mL	0.1161 mL	0.2323 mL	1.1615 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc