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SFI003

Name: SFI003
Brand: TargetMol
SKU: T72068
Price: 76 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T72068Cas No. 2361332-90-1

SFI003 is a novel SRSF3 inhibitor that exerts anticancer activity against colorectal cancer by modulating the SRSF3 / DHCR24 / ROS axis and driving apoptosis in CRC cells through the SRSF3 / DHCR24 / reactive oxygen species (ROS) axis.

SFI003

🥰Excellent

Purity: 98.92%

Catalog No. T72068Cas No. 2361332-90-1

Pack Size	Price	Availability
1 mg	$76	In Stock
5 mg	$186	In Stock
10 mg	$298	In Stock
25 mg	$550	In Stock
50 mg	$792	In Stock
1 mL x 10 mM (in DMSO)	$193	In Stock

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Bulk & Custom

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:98.92%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	SFI003 is a novel SRSF3 inhibitor that exerts anticancer activity against colorectal cancer by modulating the SRSF3 / DHCR24 / ROS axis and driving apoptosis in CRC cells through the SRSF3 / DHCR24 / reactive oxygen species (ROS) axis.
Targets&IC50	HCT116 cells:8.78 µM, SW480 cells:48.67 µM

Chemical Properties

Molecular Weight	363.44
Formula	C₁₉H₁₇N₅OS
Cas No.	2361332-90-1
Smiles	C(=N\NC1=NC(=CS1)C2=CC=C(OC)C=C2)(\C)/C=3NC=4C(N3)=CC=CC4
Relative Density.	1.36 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (137.57 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7515 mL	13.7574 mL	27.5149 mL	137.5743 mL
5 mM	0.5503 mL	2.7515 mL	5.5030 mL	27.5149 mL
10 mM	0.2751 mL	1.3757 mL	2.7515 mL	13.7574 mL
20 mM	0.1376 mL	0.6879 mL	1.3757 mL	6.8787 mL
50 mM	0.0550 mL	0.2751 mL	0.5503 mL	2.7515 mL
100 mM	0.0275 mL	0.1376 mL	0.2751 mL	1.3757 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc