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SFI003

Name: SFI003
Brand: TargetMol
SKU: T72068
Price: 73 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T72068 Copy Product Info

Purity: 99.44%

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SFI003 is a small-molecule inhibitor and an SRSF3 inhibitor with favorable pharmacokinetic properties, bioavailability, and tumor distribution capacity, inducing apoptosis in colorectal cancer cells through the SRSF3/DHCR24/ROS axis and exhibiting potent antitumor activity.

Cas No. 2361332-90-1

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Pack Size	Price	USA Stock	Global Stock
1 mg	$73	In Stock	In Stock
5 mg	$176	In Stock	In Stock
10 mg	$283	In Stock	In Stock
25 mg	$550	In Stock	In Stock
50 mg	$792	In Stock	In Stock
100 mg	$1,080	-	In Stock
200 mg	$1,490	Inquiry	Inquiry
1 mL x 10 mM (in DMSO)	$185	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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Custom-made molecule. TargetMol’s expert synthesis team delivers cost-effective solutions. Contact us for inquiries. Committed to serving you.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.44%

Appearance:Solid

Color:Orange

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	SFI003 is a small-molecule inhibitor and an SRSF3 inhibitor with favorable pharmacokinetic properties, bioavailability, and tumor distribution capacity, inducing apoptosis in colorectal cancer cells through the SRSF3/DHCR24/ROS axis and exhibiting potent antitumor activity.
Targets & IC50	HCT116 cells:8.78 µM, SW480 cells:48.67 µM
In vitro	Methods: HCT116 and SW480 cells were treated with SFI003 (0-50 μM) for 0-72 hours, and cell proliferation, apoptosis, and ROS generation were detected. Results: SFI003 inhibited cell proliferation in a dose- and time-dependent manner with IC50 values of 8.67 µM (HCT116) and 48.67 µM (SW480); simultaneously induced cell apoptosis and promoted ROS generation in a dose-dependent manner.[1]
In vivo	Methods: In HCT-116 and SW480 xenograft SCID mouse models, SFI003 (100, 200 mg/kg) was administered orally for 2 consecutive weeks to evaluate in vivo antitumor activity. Results: SFI003 dose-dependently inhibited tumor growth, demonstrating in vivo antitumor activity.[1]

Chemical Properties

Molecular Weight	363.44
Formula	C₁₉H₁₇N₅OS
Cas No.	2361332-90-1
Smiles	C(=N\NC1=NC(=CS1)C2=CC=C(OC)C=C2)(\C)/C=3NC=4C(N3)=CC=CC4
Relative Density.	1.36 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (137.57 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7515 mL	13.7574 mL	27.5149 mL	137.5743 mL
5 mM	0.5503 mL	2.7515 mL	5.5030 mL	27.5149 mL
10 mM	0.2751 mL	1.3757 mL	2.7515 mL	13.7574 mL
20 mM	0.1376 mL	0.6879 mL	1.3757 mL	6.8787 mL
50 mM	0.0550 mL	0.2751 mL	0.5503 mL	2.7515 mL
100 mM	0.0275 mL	0.1376 mL	0.2751 mL	1.3757 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.