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ATIC-IN-2

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Catalog No. T204433Cas No. 67095-44-7

ATIC-IN-2 (Compound 1) is a competitive inhibitor of the bifunctional enzyme AICAR transformylase/IMP cyclohydrolase (ATIC) that binds to the inosine monophosphate cyclohydrolase (IMPCH) domain with a Ki value of 0.13 μM, ATIC-IN-2 is commonly employed in purine biosynthesis research to dissect nucleotide metabolism, enzyme regulation, and metabolic vulnerabilities in cancer cells.

ATIC-IN-2

ATIC-IN-2

😃Good
Catalog No. T204433Cas No. 67095-44-7
ATIC-IN-2 (Compound 1) is a competitive inhibitor of the bifunctional enzyme AICAR transformylase/IMP cyclohydrolase (ATIC) that binds to the inosine monophosphate cyclohydrolase (IMPCH) domain with a Ki value of 0.13 μM, ATIC-IN-2 is commonly employed in purine biosynthesis research to dissect nucleotide metabolism, enzyme regulation, and metabolic vulnerabilities in cancer cells.
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1 mg$29-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Product Introduction

Bioactivity
Description
ATIC-IN-2 (Compound 1) is a competitive inhibitor of the bifunctional enzyme AICAR transformylase/IMP cyclohydrolase (ATIC) that binds to the inosine monophosphate cyclohydrolase (IMPCH) domain with a Ki value of 0.13 μM, ATIC-IN-2 is commonly employed in purine biosynthesis research to dissect nucleotide metabolism, enzyme regulation, and metabolic vulnerabilities in cancer cells.
In vitro
In biochemical assays, ATIC-IN-2 functioned as a competitive inhibitor and transition state analogue targeting the IMPCH domain of the bifunctional enzyme ATIC with a Ki value of 0.13 μM [1].
Chemical Properties
Molecular Weight188.17
FormulaC4H4N4O3S
Cas No.67095-44-7
SmilesO=C1NS(=O)(=O)NC=2N=CNC12
ColorRed
AppearanceSolid
Storage & Solubility Information
Storagestore at low temperature | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 40 mg/mL (212.57 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM5.3143 mL26.5717 mL53.1434 mL265.7172 mL
5 mM1.0629 mL5.3143 mL10.6287 mL53.1434 mL
10 mM0.5314 mL2.6572 mL5.3143 mL26.5717 mL
20 mM0.2657 mL1.3286 mL2.6572 mL13.2859 mL
50 mM0.1063 mL0.5314 mL1.0629 mL5.3143 mL
100 mM0.0531 mL0.2657 mL0.5314 mL2.6572 mL

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Stock solution preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (stock solution concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
The above example illustrates how to use "In Vivo Formulation Calculator" and does not represent a recommended formulation for any specific compound. Please select an appropriate dissolution method based on your experimental animals and route of administration.
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2 Enter the in vivo formulation:
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