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Dihomo-γ-linolenic acid

Name: Dihomo-γ-linolenic acid
Brand: TargetMol
SKU: TQ0262
Price: 50 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. TQ0262Cas No. 1783-84-2

Alias Ro 12-1989, Diroleuton, all-cis-8,11,14-Eicosatrienoic acid

Dihomo-γ-linolenic acid (DGLA) is a fatty acid widely found in plants with antitumor and antiproliferative effects, inhibits the growth of xenograft tumor cells, and can be used in the study of inflammation-related diseases such as rheumatoid arthritis, atherosclerosis, and atopic dermatitis.

Dihomo-γ-linolenic acid

🥰Excellent

Purity: 98.1%

Catalog No. TQ0262Alias Ro 12-1989, Diroleuton, all-cis-8,11,14-Eicosatrienoic acidCas No. 1783-84-2

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$50	-	In Stock
5 mg	$113	-	In Stock
10 mg	$163	-	In Stock
25 mg	$273	-	In Stock
50 mg	$395	-	In Stock
100 mg	$589	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:98.1%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Dihomo-γ-linolenic acid (DGLA) is a fatty acid widely found in plants with antitumor and antiproliferative effects, inhibits the growth of xenograft tumor cells, and can be used in the study of inflammation-related diseases such as rheumatoid arthritis, atherosclerosis, and atopic dermatitis.
In vitro	In THP-1 macrophages, Dihomo-γ-linolenic acid (50 μM; 24 hours) attenuates IFN-γ-induced phosphorylation of STAT1 at serine 727[2].
In vivo	In 48 four-week-old female nude mice, administration of 8 mg per mouse via oral gavage twice a week for 35 days suppressed the metastatic potential of D5D-KD tumors[3].
Synonyms	Ro 12-1989, Diroleuton, all-cis-8,11,14-Eicosatrienoic acid

Chemical Properties

Molecular Weight	306.48
Formula	C₂₀H₃₄O₂
Cas No.	1783-84-2
Smiles	CCCCC\C=C/C\C=C/C\C=C/CCCCCCC(O)=O
Relative Density.	0.917g/cm3
Color	Transparent
Appearance	Liquid

Storage & Solubility Information

Storage

store at low temperature,keep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 100 mg/mL (326.29 mM), Sonication is recommended.

DMSO: 80 mg/mL (261.03 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (10.77 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/Ethanol

	1mg	5mg	10mg	50mg
1 mM	3.2629 mL	16.3143 mL	32.6286 mL	163.1428 mL
5 mM	0.6526 mL	3.2629 mL	6.5257 mL	32.6286 mL
10 mM	0.3263 mL	1.6314 mL	3.2629 mL	16.3143 mL
20 mM	0.1631 mL	0.8157 mL	1.6314 mL	8.1571 mL
50 mM	0.0653 mL	0.3263 mL	0.6526 mL	3.2629 mL
100 mM	0.0326 mL	0.1631 mL	0.3263 mL	1.6314 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc