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Remibrutinib

Name: Remibrutinib
Brand: TargetMol
SKU: T16730
Price: 98 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T16730Cas No. 1787294-07-8

Remibrutinib inhibits BTK activity with an IC50 value of 0.023 μM in blood. Remibrutinib is an effective and orally active Bruton tyrosine kinase inhibitor (IC50: 1 nM). Remibrutinib has the potential for Chronic urticaria (CU) treatment.

Remibrutinib

🥰Excellent

Purity: 99.81%

Catalog No. T16730Cas No. 1787294-07-8

Pack Size	Price	Availability
1 mg	$98	In Stock
5 mg	$233	In Stock
10 mg	$378	In Stock
25 mg	$635	In Stock
50 mg	$793	In Stock
100 mg	$1,220	In Stock
200 mg	$1,650	In Stock
1 mL x 10 mM (in DMSO)	$261	In Stock

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Purity:99.81%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Remibrutinib inhibits BTK activity with an IC50 value of 0.023 μM in blood. Remibrutinib is an effective and orally active Bruton tyrosine kinase inhibitor (IC50: 1 nM). Remibrutinib has the potential for Chronic urticaria (CU) treatment.
Targets&IC50	IL-8 (Cell-free assay):2.5 nM, BTK (Cell-free assay):1.3 nM, CD69 (Cell-free assay):18 nM, Btk enzymatic (B cell):0.023 μM, BTK:1 nM
In vitro	Remibrutinib inhibits Btk enzymatic activity (IC50: 1 nM in a biochemical enzyme assay). Remibrutinib inhibits Btk enzymatic activity in the blood (IC50: 0.023 μM in vitro B cell activation assay), the whole blood is collected from the abdominal aorta of anesthetized adult male Lewis rats[1].

Chemical Properties

Molecular Weight	507.53
Formula	C₂₇H₂₇F₂N₅O₃
Cas No.	1787294-07-8
Smiles	CN(CCOc1c(N)ncnc1-c1cc(F)cc(NC(=O)c2ccc(cc2F)C2CC2)c1C)C(=O)C=C
Relative Density.	1.332 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 240 mg/mL (472.88 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (9.85 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9703 mL	9.8516 mL	19.7033 mL	98.5163 mL
5 mM	0.3941 mL	1.9703 mL	3.9407 mL	19.7033 mL
10 mM	0.1970 mL	0.9852 mL	1.9703 mL	9.8516 mL
20 mM	0.0985 mL	0.4926 mL	0.9852 mL	4.9258 mL
50 mM	0.0394 mL	0.1970 mL	0.3941 mL	1.9703 mL
100 mM	0.0197 mL	0.0985 mL	0.1970 mL	0.9852 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc