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TCN238

Name: TCN238
Brand: TargetMol
SKU: T7494
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7494Cas No. 125404-04-8

Alias TCN 238

TCN238 is an orally bioavailable positive allosteric modulator of the metabotropic glutamate receptor 4 (mGluR4with an EC50 of 1 μM).

TCN238

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Purity: 99.92%

Catalog No. T7494Alias TCN 238Cas No. 125404-04-8

TCN238 is an orally bioavailable positive allosteric modulator of the metabotropic glutamate receptor 4 (mGluR4with an EC50 of 1 μM).

Pack Size	Price	Availability
5 mg	$31	In Stock
10 mg	$53	In Stock
25 mg	$112	In Stock
50 mg	$192	In Stock
100 mg	$333	In Stock
200 mg	$479	In Stock
1 mL x 10 mM (in DMSO)	$34	In Stock

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Purity:99.92%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	TCN238 is an orally bioavailable positive allosteric modulator of the metabotropic glutamate receptor 4 (mGluR4with an EC50 of 1 μM).
Targets&IC50	mGluR4:1 μM (EC50)
In vitro	TCN238 has a greater than 30-fold selectivity for mGluR4 over mGluR5 using human recombinant receptors in CHO-K1 cells[1].
In vivo	TCN238 has no activity at the adenosine A2A, serotonin 5-HT1A, or α2A-adrenergic receptors at concentrations up to 10 μM.?In a haloperidol-induced catalepsy rat model of Parkinson's disease, it dose-dependently reduces catalepsy with an ED50 of approximately 1 mg/kg.?TCN 238 administration in rats leads to downregulation of the mGluR4 gene, GRM4, in the hippocampus and the gene for the GABAA receptor α subunit, GABRA1, in the frontal cortex without affecting hippocampal-dependent memory[1].
Synonyms	TCN 238

Chemical Properties

Molecular Weight	197.24
Formula	C₁₂H₁₁N₃
Cas No.	125404-04-8
Smiles	Nc1nccc(\C=C\c2ccccc2)n1
Relative Density.	no data available
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 150 mg/mL (760.49 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.0700 mL	25.3498 mL	50.6997 mL	253.4983 mL
5 mM	1.0140 mL	5.0700 mL	10.1399 mL	50.6997 mL
10 mM	0.5070 mL	2.5350 mL	5.0700 mL	25.3498 mL
20 mM	0.2535 mL	1.2675 mL	2.5350 mL	12.6749 mL
50 mM	0.1014 mL	0.5070 mL	1.0140 mL	5.0700 mL
100 mM	0.0507 mL	0.2535 mL	0.5070 mL	2.5350 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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