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OPC-167832

Name: OPC-167832
Brand: TargetMol
SKU: T37880
Rating: 4.5 (1 reviews)

(Synonyms: Quabodepistat, OPC167832, OPC 167832) Copy Product Info

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Synonyms: Quabodepistat, OPC167832, OPC 167832

Catalog No. T37880 Copy Product Info

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OPC-167832 is a highly potent and orally bioavailable dprE1 inhibitor with an IC₅₀ of 0.258 μM. It exhibits anti-mycobacterial activity against Mycobacterium tuberculosis and can be used in tuberculosis-related research.

Cas No. 1883747-71-4

Pack Size	Price	USA Stock	Global Stock
25 mg	$1,170	10-14 weeks	10-14 weeks
50 mg	$1,530	10-14 weeks	10-14 weeks
100 mg	$2,440	10-14 weeks	10-14 weeks

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Appearance:Solid

Color:White

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Product Introduction

Bioactivity

Description	OPC-167832 is a highly potent and orally bioavailable dprE1 inhibitor with an IC₅₀ of 0.258 μM. It exhibits anti-mycobacterial activity against Mycobacterium tuberculosis and can be used in tuberculosis-related research.
In vitro	Methods: In vitro drug sensitivity testing of OPC-167832 was performed on Mycobacterium tuberculosis and various standard strains, and its bacteriostatic and bactericidal activities against intracellular Mycobacterium tuberculosis were determined. Results： 1 OPC-167832 exhibited potent inhibitory activity against the Mycobacterium tuberculosis laboratory strains H37Rv and Kurono, with a MIC of 0.0005 μg/mL for both, while it had almost no antibacterial activity against standard strains of aerobic and anaerobic non-mycobacterial bacteria. 2 The IC₉₀ of OPC-167832 against intracellular Mycobacterium tuberculosis was less than 100%, and the bacteriostatic concentrations against H37Rv and Kurono strains were 0.0048 μg/mL and 0.0027 μg/mL, respectively; it could exert intracellular bactericidal effect at low concentrations, and the bactericidal activity tended to be saturated when the concentration was ≥0.004 μg/mL [1].
In vivo	Methods: OPC-167832 was administered orally at doses of 0.625–10 mg/kg to detect its pharmacokinetics and lung tissue distribution; oral administration at the same doses was performed for 4 weeks to observe changes in lung tissue CFU; intragastric administration of 2.5 mg/kg combined with DCMB was conducted for 12 weeks to evaluate the combined therapeutic effect. Results： 1 OPC-167832 had good pharmacokinetic properties after oral administration, with a time to peak concentration (tmax) of 0.5–1.0 h and an elimination half-life (t1/2) of 1.3–2.1 h; the drug concentration in the lungs was approximately twice that in the plasma, and the Cmax and AUCt in both plasma and lungs were dose-dependent. 2 Compared with the vehicle group, OPC-167832 (0.625–10 mg/kg, oral administration, 4 weeks) significantly reduced lung CFU, and the lung CFU decreased in a dose-dependent manner within the dose range of 0.625–2.5 mg/kg. 3 OPC-167832 (2.5 mg/kg, intragastric administration, combined with DCMB, 12 weeks) showed the optimal therapeutic effect; the lung CFU of mice was below the detection limit after 6 weeks of treatment, and the lung bacteria of all mice were eradicated after 8 weeks of treatment [1].
Synonyms	Quabodepistat, OPC167832, OPC 167832

Chemical Properties

Molecular Weight	456.84
Formula	C₂₁H₂₀ClF₃N₂O₄
Cas No.	1883747-71-4
Smiles	O(C[C@@]1(O)[C@H](O)CN(CC1)C2=C(F)C=C(Cl)C=C2F)C3=C4C(=C(F)C=C3)NC(=O)CC4

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 144 mg/mL (315.21 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1890 mL	10.9448 mL	21.8895 mL	109.4475 mL
5 mM	0.4378 mL	2.1890 mL	4.3779 mL	21.8895 mL
10 mM	0.2189 mL	1.0945 mL	2.1890 mL	10.9448 mL
20 mM	0.1094 mL	0.5472 mL	1.0945 mL	5.4724 mL
50 mM	0.0438 mL	0.2189 mL	0.4378 mL	2.1890 mL
100 mM	0.0219 mL	0.1094 mL	0.2189 mL	1.0945 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.