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CYP11B2-IN-1

🥰Excellent
Catalog No. T10922Cas No. 1356479-78-1

CYP11B2-IN-1 is an effective and selective inhibitor of CYP11B2 with IC50s of 2.3 nM and 142 nM for CYP11B2 and CYP11B1.

CYP11B2-IN-1

CYP11B2-IN-1

🥰Excellent
Purity: 99.89%
Catalog No. T10922Cas No. 1356479-78-1
CYP11B2-IN-1 is an effective and selective inhibitor of CYP11B2 with IC50s of 2.3 nM and 142 nM for CYP11B2 and CYP11B1.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$42In StockIn Stock
5 mg$98In StockIn Stock
10 mg$156In StockIn Stock
25 mg$268In StockIn Stock
50 mg$392In StockIn Stock
1 mL x 10 mM (in DMSO)$39In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Purity:99.89%
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Product Introduction

Bioactivity
Description
CYP11B2-IN-1 is an effective and selective inhibitor of CYP11B2 with IC50s of 2.3 nM and 142 nM for CYP11B2 and CYP11B1.
Targets&IC50
CYP11B2:2.3 nM, CYP11B1:142 nM
In vitro
The IC50 of CYP11B2-IN-1 for CYP19 is 1021 nM[1].
In vivo
CYP11B2-IN-1 dose-dependently produces aldosterone lowering efficacy without affecting cortisol levels in rhesus pharmacodynamic models. CYP11B2-IN-1 (0.01 and 0.3 mg/kg; i.v.) reduces aldosterone AUC of 62% and 95%, respectively[1].
Chemical Properties
Molecular Weight311.35
FormulaC18H18FN3O
Cas No.1356479-78-1
SmilesFC=1C=C2N(C(=NC2=CC1)C=3C=C(C(C)(C)O)C=NC3)C4CC4
Relative Density.1.34 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 50 mg/mL (160.59 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.42 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.2118 mL16.0591 mL32.1182 mL160.5910 mL
5 mM0.6424 mL3.2118 mL6.4236 mL32.1182 mL
10 mM0.3212 mL1.6059 mL3.2118 mL16.0591 mL
20 mM0.1606 mL0.8030 mL1.6059 mL8.0295 mL
50 mM0.0642 mL0.3212 mL0.6424 mL3.2118 mL
100 mM0.0321 mL0.1606 mL0.3212 mL1.6059 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Cytochrome P450CYP11B2-IN-1CYP-11B2-IN-1CYP11B2IN1CYP11B2 IN 1
Related Tags: buy CYP11B2-IN-1 | purchase CYP11B2-IN-1 | CYP11B2-IN-1 cost | order CYP11B2-IN-1 | CYP11B2-IN-1 chemical structure | CYP11B2-IN-1 in vivo | CYP11B2-IN-1 in vitro | CYP11B2-IN-1 formula | CYP11B2-IN-1 molecular weight
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