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ZD-2138

Catalog No. T68173 CAS 140841-32-3

Synonyms: Ici-D2138

ZD-2138 is a potent and selective specific inhibitor of 5-lipoxygenase (5-LOX) that inhibits allergen-induced pulmonary bronchoconstriction and reduces neurally-induced fast-acting kallikrein-ergic constriction of isolated airways in guinea pigs.ZD-2138 can be used for the treatment of asthma disease.

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ZD-2138, CAS 140841-32-3

Pack Size	Availability	Price/USD
1 mg	In stock	$ 133.00
5 mg	In stock	$ 320.00
10 mg	In stock	$ 470.00
25 mg	In stock	$ 772.00
50 mg	In stock	$ 1,080.00
100 mg	In stock	$ 1,460.00
500 mg	In stock	$ 2,920.00

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Purity: 100%

Biological Description

Chemical Properties

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Description	ZD-2138 is a potent and selective specific inhibitor of 5-lipoxygenase (5-LOX) that inhibits allergen-induced pulmonary bronchoconstriction and reduces neurally-induced fast-acting kallikrein-ergic constriction of isolated airways in guinea pigs.ZD-2138 can be used for the treatment of asthma disease.
In vitro	The 5-lipoxygenase inhibitor ZD-2138 (1 μM) significantly inhibited these neurally mediated tachykinergic contractions, by approximately 50%, yet had no effect on the contractions evoked by stimulating tachykinergic fibers in an action potential-independent fashion with capsaicin or by exogenously applied neurokinin A.[1]

Synonyms	Ici-D2138
Molecular Weight	397.44
Formula	C23H24FNO4
CAS No.	140841-32-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 15 mg/mL (37.74 mM), Sonication is recommended.

References and Literature

1. McAlexander MA, et al. Inhibition of 5-lipoxygenase diminishes neurally evoked tachykinergic contraction of guinea pig isolated airway. J Pharmacol Exp Ther. 1998;285(2):602-607. 2. Werz O, et al. Nonredox 5-lipoxygenase inhibitors require glutathione peroxidase for efficient inhibition of 5-lipoxygenase activity. Mol Pharmacol. 1998;54(2):445-451.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Bioactive Compounds Library Max Bioactive Compound Library

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Keywords

ZD-2138 140841-32-3 Metabolism Lipoxygenase Ici-D2138 Ici-D-2138 Ici-D 2138 ZD2138 ZD 2138 inhibitor inhibit

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