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LXR agonist 4
Catalog No. T214397 Copy Product Info
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LXR agonist4 is a selective LXR inverse agonist, with IC50 values of 7.6 μM for LXRα and 2.9 μM for LXRβ. It exhibits selectivity for RORα and FXR. Additionally, LXR agonist4 markedly inhibits the expression of SREBP1c without affecting the expression of ABCA1 or APOE. It possesses anti-lipogenic properties and can prevent fat accumulation induced by fatty acids. This compound is useful for research in atherosclerosis and metabolic dysfunction-associated steatotic liver disease (MASLD).
LXR agonist 4
Copy Product Info🥰Excellent
Catalog No. T214397
LXR agonist4 is a selective LXR inverse agonist, with IC50 values of 7.6 μM for LXRα and 2.9 μM for LXRβ. It exhibits selectivity for RORα and FXR. Additionally, LXR agonist4 markedly inhibits the expression of SREBP1c without affecting the expression of ABCA1 or APOE. It possesses anti-lipogenic properties and can prevent fat accumulation induced by fatty acids. This compound is useful for research in atherosclerosis and metabolic dysfunction-associated steatotic liver disease (MASLD).
LXR agonist 4
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | LXR agonist4 is a selective LXR inverse agonist, with IC50 values of 7.6 μM for LXRα and 2.9 μM for LXRβ. It exhibits selectivity for RORα and FXR. Additionally, LXR agonist4 markedly inhibits the expression of SREBP1c without affecting the expression of ABCA1 or APOE. It possesses anti-lipogenic properties and can prevent fat accumulation induced by fatty acids. This compound is useful for research in atherosclerosis and metabolic dysfunction-associated steatotic liver disease (MASLD). |
| Targets&IC50 | LXRα:7.6 μM |
| In vitro | LXR agonist 4 (compound 3) at a concentration of 30 μM does not inhibit the proliferation of HEK293T or HepG2 cells over a period of 4 to 24 hours. When applied for 24 hours, this compound suppresses the expression of SREBP1c in HepG2 cells without altering the levels of ABCA1 or APOE. After 72 hours of treatment, LXR agonist 4 demonstrates anti-adipogenic properties and effectively mitigates fatty acid-induced steatosis in HepG2 cells. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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