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N-[2-(5-Chloro-1H-indol-3-yl)ethyl]-4'-cyanobiphenyl-2-carboxaMide

🥰Excellent
Catalog No. T60041Cas No. 1383373-65-6

N-[2-(5-Chloro-1H-indol-3-yl)ethyl]-4'-cyanobiphenyl-2-carboxaMide, a TAU cytotoxicity inhibitor, inhibits LDH leakage of M17-TAU P301L cells with EC50 of 325nM.

N-[2-(5-Chloro-1H-indol-3-yl)ethyl]-4'-cyanobiphenyl-2-carboxaMide

N-[2-(5-Chloro-1H-indol-3-yl)ethyl]-4'-cyanobiphenyl-2-carboxaMide

🥰Excellent
Purity: 99.93%
Catalog No. T60041Cas No. 1383373-65-6
N-[2-(5-Chloro-1H-indol-3-yl)ethyl]-4'-cyanobiphenyl-2-carboxaMide, a TAU cytotoxicity inhibitor, inhibits LDH leakage of M17-TAU P301L cells with EC50 of 325nM.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$117-In Stock
5 mg$268-In Stock
10 mg$395-In Stock
25 mg$592-In Stock
50 mg$828-In Stock
100 mg$1,130-In Stock
200 mg$1,530-In Stock
1 mL x 10 mM (in DMSO)$293-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information

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Purity:99.93%
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COA LCMS HNMR

Product Introduction

Bioactivity
Description
N-[2-(5-Chloro-1H-indol-3-yl)ethyl]-4'-cyanobiphenyl-2-carboxaMide, a TAU cytotoxicity inhibitor, inhibits LDH leakage of M17-TAU P301L cells with EC50 of 325nM.
Chemical Properties
Molecular Weight399.87
FormulaC24H18ClN3O
Cas No.1383373-65-6
SmilesC(CNC(=O)C1=C(C=CC=C1)C2=CC=C(C#N)C=C2)C=3C=4C(NC3)=CC=C(Cl)C4
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 55 mg/mL (137.54 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.5008 mL12.5041 mL25.0081 mL125.0406 mL
5 mM0.5002 mL2.5008 mL5.0016 mL25.0081 mL
10 mM0.2501 mL1.2504 mL2.5008 mL12.5041 mL
20 mM0.1250 mL0.6252 mL1.2504 mL6.2520 mL
50 mM0.0500 mL0.2501 mL0.5002 mL2.5008 mL
100 mM0.0250 mL0.1250 mL0.2501 mL1.2504 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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2 Enter the in vivo formulation:
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

tauN[2(5Chloro1Hindol3yl)ethyl]4'cyanobiphenyl2carboxaMideN [2 (5 Chloro 1H indol 3 yl)ethyl] 4' cyanobiphenyl 2 carboxaMideMicrotubuleAssociatedMicrotubule Associated
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