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MMAE-SMCC

Name: MMAE-SMCC
Brand: TargetMol
SKU: T18361
Price: 372 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T18361Cas No. 2021179-11-1

MMAE-SMCC comprises the antitumour microtubule inhibitor MMAE and the non-cleavable ADC linker SMCC, enabling the preparation of antibody-drug conjugates (ADCs).

MMAE-SMCC

🥰Excellent

Catalog No. T18361Cas No. 2021179-11-1

MMAE-SMCC comprises the antitumour microtubule inhibitor MMAE and the non-cleavable ADC linker SMCC, enabling the preparation of antibody-drug conjugates (ADCs).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$372	-	In Stock
5 mg	$985	-	In Stock
10 mg	$1,560	-	In Stock
25 mg	$2,320	-	In Stock
50 mg	$3,130	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description

MMAE-SMCC comprises the antitumour microtubule inhibitor MMAE and the non-cleavable ADC linker SMCC, enabling the preparation of antibody-drug conjugates (ADCs).

Chemical Properties

Molecular Weight	1140.43
Formula	C₅₈H₈₉N₇O₁₄S
Cas No.	2021179-11-1
Smiles	[C@H]([C@H](C(N[C@@H]([C@@H](O)C1=CC=CC=C1)C)=O)C)(OC)[C@]2(N(C(C[C@H]([C@@H](N(C([C@@H](NC([C@@H](N(C(CCSC3C(=O)N(CC4CCC(C(ON5C(=O)CCC5=O)=O)CC4)C(=O)C3)=O)C)[C@@H](C)C)=O)C(C)C)=O)C)[C@H](CC)C)OC)=O)CCC2)[H]
Relative Density.	1.26 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 120 mg/mL (105.22 mM)

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (3.51 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	0.8769 mL	4.3843 mL	8.7686 mL	43.8431 mL
5 mM	0.1754 mL	0.8769 mL	1.7537 mL	8.7686 mL
10 mM	0.0877 mL	0.4384 mL	0.8769 mL	4.3843 mL
20 mM	0.0438 mL	0.2192 mL	0.4384 mL	2.1922 mL
50 mM	0.0175 mL	0.0877 mL	0.1754 mL	0.8769 mL
100 mM	0.0088 mL	0.0438 mL	0.0877 mL	0.4384 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc