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MMAE-SMCC

🥰Excellent
Catalog No. T18361Cas No. 2021179-11-1

MMAE-SMCC comprises the antitumour microtubule inhibitor MMAE and the non-cleavable ADC linker SMCC, enabling the preparation of antibody-drug conjugates (ADCs).

MMAE-SMCC

MMAE-SMCC

🥰Excellent
Purity: 97.04%
Catalog No. T18361Cas No. 2021179-11-1
MMAE-SMCC comprises the antitumour microtubule inhibitor MMAE and the non-cleavable ADC linker SMCC, enabling the preparation of antibody-drug conjugates (ADCs).
Pack SizePriceAvailabilityQuantity
1 mg$372In Stock
5 mg$985In Stock
10 mg$1,560In Stock
25 mg$2,320In Stock
50 mg$3,130In Stock
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Purity:97.04%
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Product Introduction

Bioactivity
Description
MMAE-SMCC comprises the antitumour microtubule inhibitor MMAE and the non-cleavable ADC linker SMCC, enabling the preparation of antibody-drug conjugates (ADCs).
Chemical Properties
Molecular Weight1140.43
FormulaC58H89N7O14S
Cas No.2021179-11-1
Smiles[C@H]([C@H](C(N[C@@H]([C@@H](O)C1=CC=CC=C1)C)=O)C)(OC)[C@]2(N(C(C[C@H]([C@@H](N(C([C@@H](NC([C@@H](N(C(CCSC3C(=O)N(CC4CCC(C(ON5C(=O)CCC5=O)=O)CC4)C(=O)C3)=O)C)[C@@H](C)C)=O)C(C)C)=O)C)[C@H](CC)C)OC)=O)CCC2)[H]
Relative Density.1.26 g/cm3 (Predicted)
ColorWhite
AppearanceSolid
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 120 mg/mL (105.22 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM0.8769 mL4.3843 mL8.7686 mL43.8431 mL
5 mM0.1754 mL0.8769 mL1.7537 mL8.7686 mL
10 mM0.0877 mL0.4384 mL0.8769 mL4.3843 mL
20 mM0.0438 mL0.2192 mL0.4384 mL2.1922 mL
50 mM0.0175 mL0.0877 mL0.1754 mL0.8769 mL
100 mM0.0088 mL0.0438 mL0.0877 mL0.4384 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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