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Pemirolast potassium

Name: Pemirolast potassium
Brand: TargetMol
SKU: T1425
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1425Cas No. 100299-08-9

Alias TWT-8152, BMY 26517

Pemirolast Potassium is the potassium salt form of pemirolast, a pyrimidinone derivative with antiallergic property. Pemirolast potassium (TWT-8152) exerts its action by blocking the antigen-mediated calcium ion influx into mast cells.

Pemirolast potassium

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Purity: 99.63%

Catalog No. T1425Alias TWT-8152, BMY 26517Cas No. 100299-08-9

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$30	In Stock	In Stock
10 mg	$48	In Stock	In Stock
25 mg	$68	In Stock	In Stock
50 mg	$85	In Stock	In Stock
100 mg	$126	In Stock	In Stock
200 mg	$163	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.63%

Appearance:solid

Color:White to Yellow

Resource Download

COA LCMS HNMR HPLC

Product Introduction

Pemirolast potassium AI Summary

Pemirolast potassium demonstrates antiviral activity, notably inhibiting the entry of the Ebola virus with significant potency, evidenced by AC50 values of 1.259 µM and 1258.9 nM in different assays. It also exhibits antiviral properties against SARS-CoV-2, albeit with varying efficacy. In Vero E6 cells, it showed a low inhibition index of 0.2426 for SARS-CoV-2 strain BavPat1. For SARS-CoV-2-induced cytotoxicity, it displayed 6.36% inhibition in Caco-2 cells at a 10 µM concentration over 48 hours and a 7.072% inhibition of the SARS-CoV-2 3CL-Pro protease at 20 µM. However, in Vero-6 cells, the inhibition rate was -0.09% at a 10 µM concentration after 48 hours, indicating limited efficacy. Additionally, Pemirolast potassium shows weak bioactivity in inhibiting human BSEP, MRP2, MRP3, and MRP4 activities, with IC50 values exceeding 133,000.0 nM in these assays, suggesting low potency in these transport processes..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Pemirolast Potassium is the potassium salt form of pemirolast, a pyrimidinone derivative with antiallergic property. Pemirolast potassium (TWT-8152) exerts its action by blocking the antigen-mediated calcium ion influx into mast cells.
In vitro	Pemirolast potassium inhibits the release of peptides from sensory nerves (substance P, neurokinin (NK) A, and CGRP) and inhibits the release of chemical mediators from tissue mast cells, which are commonly used in the treatment of allergic reactions.
In vivo	Pemirolast potassium inhibits the release of peptides from sensory nerves (substance P, neurokinin (NK) A, and CGRP) and inhibits the release of chemical mediators from tissue mast cells, which are commonly used in the treatment of allergic reactions.
Synonyms	TWT-8152, BMY 26517

Chemical Properties

Molecular Weight	266.31
Formula	C₁₀H₇KN₆O
Cas No.	100299-08-9
Smiles	[K+].Cc1cccn2c1ncc(c2=O)c1[n-]nnn1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 10 mM, Sonication is recommended.

DMSO: Insoluble

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	3.7550 mL	18.7751 mL	37.5502 mL	187.7511 mL
5 mM	0.7510 mL	3.7550 mL	7.5100 mL	37.5502 mL
10 mM	0.3755 mL	1.8775 mL	3.7550 mL	18.7751 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc