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Anti-Progesterone Receptor Antibody (8O274)
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Catalog No. TMAB-11773
Anti-Progesterone Receptor Antibody (8O274) is a Rabbit antibody targeting Progesterone Receptor. Anti-Progesterone Receptor Antibody (8O274) can be used in IHC-P,IHC-Fr,IF,WB.
Anti-Progesterone Receptor Antibody (8O274)
Anti-Progesterone Receptor Antibody (8O274)
😃Good
Catalog No. TMAB-11773
Anti-Progesterone Receptor Antibody (8O274) is a Rabbit antibody targeting Progesterone Receptor. Anti-Progesterone Receptor Antibody (8O274) can be used in IHC-P,IHC-Fr,IF,WB.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 μL | $149 | 7-10 days | 7-10 days | |
| 50 μL | $264 | 7-10 days | 7-10 days | |
| 100 μL | $472 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-Progesterone Receptor Antibody (8O274) is a Rabbit antibody targeting Progesterone Receptor. Anti-Progesterone Receptor Antibody (8O274) can be used in IHC-P,IHC-Fr,IF,WB. |
| Ig Type | IgG |
| Clone | 8O274 |
| Reactivity | Human |
| Application | |
| Recommended Dose | IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500; WB: 1:500-2000 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Subcellular Localization | Nucleus. Cytoplasm. Note=Nucleoplasmic shuttling is both homone- and cell cycle-dependent. On hormone stimulation, retained in the cytoplasm in the G(1) and G(2)/M phases. Isoform A: Nucleus. Cytoplasm. Note=Mainly nuclear. |
| Tissue Specificity | Isoform A: Nucleus. Cytoplasm. Note=Mainly nuclear. |
| Construction | Recombinant Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | PBS, Glycerol, BSA. |
| Concentration | 1mg/ml |
| Research Background | Estrogen and progesterone receptor are members of a family of transcription factors that are regulated by the binding of their cognate ligands. The interaction of hormone-bound estrogen receptors with estrogen responsive elements(EREs) alters transcription of ERE-containing genes. The carboxy terminal region of the estrgen receptor contains the ligand binding domain, the amino terminus serves as the transactivation domain, and the DNA binding domain is centrally located. Two forms of estrogen receptor have been identified, ER alpha and ER beta. ER alpha and ER beta have been shown to be differentially activated by various ligands. The biological response to progesterone is mediated by two distinct forms of the human progesterone receptor (hPR-Aand hPR-B), which arise from alternative splicing. In most cells, hPR-B functions as a transcriptional activator of progesterone-responsive gene, whereas hPR-A function as a transcriptional inhibitor of all steroid hormone receptors. |
| Immunogen | A synthesized peptide: human Progesterone receptor |
| Antigen Species | Human |
| Gene Name | PGR |
| Gene ID | |
| Protein Name | Progesterone receptor |
| Uniprot ID | |
| Function | The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Progesterone receptor isoform B (PRB) is involved activation of c-SRC/MAPK signaling on hormone stimulation.
Isoform A is inactive in stimulating c-Src/MAPK signaling on hormone stimulation. |
| Molecular Weight | Theoretical: 103 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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