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Ilaprazole sodium hydrate

Catalog No. T78218 CAS 2322264-11-7

Synonyms: IY-81149 sodium hydrate

Ilaprazole (IY-81149) sodium hydrate is an orally active proton pump inhibitor that irreversibly inhibits H+/K+-ATPase in rabbit parietal cells with a dose-dependent IC50 of 6 μM. It is employed in gastric ulcer research and acts as a potent inhibitor of T-lymphokine-activated killer cell-originated protein kinase (TOPK) [1] [2].

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Ilaprazole sodium hydrate Chemical Structure

Ilaprazole sodium hydrate, CAS 2322264-11-7

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Description	Ilaprazole (IY-81149) sodium hydrate is an orally active proton pump inhibitor that irreversibly inhibits H+/K+-ATPase in rabbit parietal cells with a dose-dependent IC50 of 6 μM. It is employed in gastric ulcer research and acts as a potent inhibitor of T-lymphokine-activated killer cell-originated protein kinase (TOPK) [1] [2].
In vitro	In parietal cells stimulated by histamine, the IC50 of Ilaprazole (IY-81149) sodium hydrate for the accumulation of 14C-aminopyrine is 9 nM [1].
In vivo	Ilaprazole sodium hydrate, administered intraduodenally (3-30 mg/kg; i.d.), dose-dependently inhibits gastric acid secretion [1]. In anesthetized rats, it dose-dependently increases gastric pH, while histamine infusion reduces gastric pH. Intravenously, the ED50 values for Ilaprazole sodium hydrate and Omeprazole are 1.2 mg/kg and 1.4 mg/kg respectively; for intraduodenal administration, they are 3.9 mg/kg and 4.1 mg/kg respectively. Ilaprazole sodium hydrate also significantly suppresses pentagastrin-stimulated gastric secretion, with an ED50 of 2.1 mg/kg compared to Omeprazole's 3.5 mg/kg. Additionally, Ilaprazole sodium hydrate strongly inhibits gastric acid secretion in fistula rats, with intraduodenal ED50 values of 0.43 mg/kg for Ilaprazole sodium hydrate and 0.68 mg/kg for Omeprazole [1].

Synonyms	IY-81149 sodium hydrate
Molecular Weight	424.45
Formula	C19H21N4NaO4S
CAS No.	2322264-11-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Related Products

Related compounds with same targets

Lansoprazole Sulfide D4 Omeprazole sulfide Pumaprazole Pantoprazole Vonoprazan Fumarate Chebulinic acid Abscisic Acid Abeprazan hydrochloride

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Keywords

Ilaprazole sodium hydrate 2322264-11-7 Membrane transporter/Ion channel Proton pump IY-81149 sodium Hydrate IY-81149 sodium hydrate Ilaprazole sodium Hydrate inhibitor inhibit

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