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BMS-919373

Name: BMS-919373
Brand: TargetMol
SKU: T30544
Price: 259 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T30544Cas No. 1272353-82-8

Alias BMS919373, BMS 919373

BMS-919373 is a potassium channel Kv1.5 (KCNA5) inhibitor for atrial fibrillation and acute coronary syndrome.

BMS-919373

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Purity: 99.01%

Catalog No. T30544Alias BMS919373, BMS 919373Cas No. 1272353-82-8

BMS-919373 is a potassium channel Kv1.5 (KCNA5) inhibitor for atrial fibrillation and acute coronary syndrome.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$259	In Stock	In Stock
5 mg	$635	In Stock	In Stock
10 mg	$893	In Stock	In Stock
25 mg	$1,320	In Stock	In Stock
50 mg	$1,780	In Stock	In Stock
100 mg	$2,390	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$691	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.01%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

BMS-919373 AI Summary

BMS-919373 exhibits significant bioactivities, including potent inhibition of recombinant human Kv1.5 expressed in mouse L929 cells with an IC50 of 46.0 nM and inhibition of human ERG expressed in HEK293 cells with an IC50 of 1900.0 nM. The compound shows high plasma protein binding in both human and rat plasma (>99.0%) and demonstrates selectivity towards Kv1.5 over other channels with selectivity ratios greater than 200.0. It has good oral bioavailability across various animal models and exhibits antiatrial fibrillation activity in a methoxamine-sensitized rabbit model, as well as specific plasma concentration effects in a pacing-induced mongrel dog heart failure model. Additionally, BMS-919373 shows varying cell viability effects across different cell types, promoting growth in HEK293T cells (growth rates 0.01 to 1.0), having mixed effects in U2OS cells (growth rates -0.7 to 0.98), and showing potential cytotoxicity in human fibroblast cells (mostly negative growth rates)..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	BMS-919373 is a potassium channel Kv1.5 (KCNA5) inhibitor for atrial fibrillation and acute coronary syndrome.
Synonyms	BMS919373, BMS 919373

Chemical Properties

Molecular Weight	468.53
Formula	C₂₅H₂₀N₆O₂S
Cas No.	1272353-82-8
Smiles	N(CC1=CC=CC=N1)C=2C=3C(=CC=CC3N=C(N2)C=4C=C(S(N)(=O)=O)C=NC4)C5=CC=CC=C5
Relative Density.	1.393 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 27.5 mg/mL (58.69 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.27 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1343 mL	10.6717 mL	21.3434 mL	106.7168 mL
5 mM	0.4269 mL	2.1343 mL	4.2687 mL	21.3434 mL
10 mM	0.2134 mL	1.0672 mL	2.1343 mL	10.6717 mL
20 mM	0.1067 mL	0.5336 mL	1.0672 mL	5.3358 mL
50 mM	0.0427 mL	0.2134 mL	0.4269 mL	2.1343 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc