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Cosalane

Name: Cosalane
Brand: TargetMol
SKU: T23910
Price: 372 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: NSC-658586, NSC 658586, NSC 640067) Copy Product Info

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Synonyms: NSC-658586, NSC 658586, NSC 640067

Catalog No. T23910 Copy Product Info

Purity: 99.78%

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Cosalane (NSC 658586) is a small-molecule inhibitor and a CCR7 and CXCR2 antagonist (IC50 = 2.43 μM and 0.66 μM, respectively), with broad-spectrum antiviral activity that blocks HIV-1, HIV-2, and other viral replication, used for HIV treatment and mitigation of acute graft-versus-host disease in allogeneic hematopoietic stem cell transplantation.

Cas No. 154212-56-3

Pack Size	Price	USA Stock	Global Stock
1 mg	$372	In Stock	In Stock
5 mg	$868	In Stock	In Stock
10 mg	$1,070	In Stock	In Stock
25 mg	$1,590	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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Custom-made molecule. TargetMol’s expert synthesis team delivers cost-effective solutions. Contact us for inquiries. Committed to serving you.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.78%

ee:99.84%

Appearance:Solid

Color:White

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COA CSFC HNMR LCMS

Product Introduction

Bioactivity

Description	Cosalane (NSC 658586) is a small-molecule inhibitor and a CCR7 and CXCR2 antagonist (IC50 = 2.43 μM and 0.66 μM, respectively), with broad-spectrum antiviral activity that blocks HIV-1, HIV-2, and other viral replication, used for HIV treatment and mitigation of acute graft-versus-host disease in allogeneic hematopoietic stem cell transplantation.
Targets & IC50	HSA:1.24 ± 0.24 nM (Ki)
In vitro	Methods: Tcon cells were treated with Cosalane (10-30 μg/mL) for 72 hours in the presence of IL-2 supplementation to observe cell growth. Results: Cosalane promoted robust growth of Tcon cells with no difference in cell numbers.[1] Methods: Human or murine cells were treated with Cosalane to detect its blocking effect on CCL19- and CCL21-induced chemotaxis and receptor activation. Results: Cosalane (10 μg/mL, 1 hour) reduced chemotaxis of human H9 cells and mouse T cells toward CCL19 and CCL21; Cosalane showed similar activity against human and murine receptor orthologs, being more effective at blocking CCL19-induced receptor activation (IC50: human 0.207 μM, murine 0.193 μM) than CCL21 (IC50: human 2.66 μM, murine 1.98 μM).[2]
In vivo	Methods: In the B6D2 mouse model, Cosalane (15 μg/mL) was administered via intravenous injection 1 hour before transplantation after in vitro cell culture, and TNF and IFN-γ levels in host colon were measured on day 14 post-transplantation; additionally, in the P815 mouse mastocytoma leukemia model, a single intravenous injection of Cosalane (15 μg/mL, after in vitro culture) was given to observe tumor growth and survival. Results: Cosalane treatment reduced TNF and IFN-γ levels in mouse colon, significantly inhibited tumor growth, and prolonged overall survival.[1] Methods: In SD rats, single intravenous injections of different doses of Cosalane (1-10 mg/kg) were administered to determine its pharmacokinetic parameters; and in normal and BC rats, single intravenous injection of Cosalane (10 mg/kg) was given to analyze plasma drug elimination. Results: The steady-state volume of distribution (Vdss) of Cosalane in rats was dose-dependent, being 23.1 mL/g at 10 mg/kg and 12.6 mL/g at 5 mg/kg; and the drug was eliminated from plasma in a bi-exponential manner.[3]
Synonyms	NSC-658586, NSC 658586, NSC 640067

Chemical Properties

Molecular Weight	767.86
Formula	C₄₅H₆₀Cl₂O₆
Cas No.	154212-56-3
Smiles	C[C@@]12[C@@]3([C@]([C@]4([C@](C)(CC3)[C@@]([C@@H](CCCC(C)C)C)(CC4)[H])[H])(CC[C@]1(C[C@@H](CCC=C(C5=CC(C(O)=O)=C(O)C(Cl)=C5)C6=CC(C(O)=O)=C(O)C(Cl)=C6)CC2)[H])[H])[H]
Relative Density.	1.191g/cm3

Storage & Solubility Information

Storage

Store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (130.23 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (4.3 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.3023 mL	6.5116 mL	13.0232 mL	65.1160 mL
5 mM	0.2605 mL	1.3023 mL	2.6046 mL	13.0232 mL
10 mM	0.1302 mL	0.6512 mL	1.3023 mL	6.5116 mL
20 mM	0.0651 mL	0.3256 mL	0.6512 mL	3.2558 mL
50 mM	0.0260 mL	0.1302 mL	0.2605 mL	1.3023 mL
100 mM	0.0130 mL	0.0651 mL	0.1302 mL	0.6512 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc