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hydrocotarnine

🥰Excellent
Catalog No. T9352Cas No. 550-10-7

hydrocotarnine is an inhibitor of Cbl.

hydrocotarnine

hydrocotarnine

🥰Excellent
Purity: 98.85%
Catalog No. T9352Cas No. 550-10-7
hydrocotarnine is an inhibitor of Cbl.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$41In StockIn Stock
5 mg$101In StockIn Stock
10 mg$158In StockIn Stock
25 mg$317In StockIn Stock
50 mg$461In StockIn Stock
100 mg$648In StockIn Stock
200 mg$873In StockIn Stock
1 mL x 10 mM (in DMSO)$94In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information

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Purity:98.85%
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COA LCMS HNMR

Product Introduction

Bioactivity
Description
hydrocotarnine is an inhibitor of Cbl.
In vivo
In vivo, inhibition of Cbl with an analgesic drug, hydrocotarnine, increases inflammasome-mediated IL-18 secretion in the colon, and protects mice from dextran sulphate sodium-induced colitis. Together, our novel findings provide new insights into the role of the SFK-Cbl axis in suppressing NLRP3 inflammasome activation and identify a novel clinical utility of hydrocortanine for disease treatment[2].
Chemical Properties
Molecular Weight221.25
FormulaC12H15NO3
Cas No.550-10-7
SmilesCOC1=C2CN(C)CCC2=CC2=C1OCO2
Relative Density.1.1514 g/cm3 (Estimated)
ColorYellow
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 55 mg/mL (248.59 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (9.04 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM4.5198 mL22.5989 mL45.1977 mL225.9887 mL
5 mM0.9040 mL4.5198 mL9.0395 mL45.1977 mL
10 mM0.4520 mL2.2599 mL4.5198 mL22.5989 mL
20 mM0.2260 mL1.1299 mL2.2599 mL11.2994 mL
50 mM0.0904 mL0.4520 mL0.9040 mL4.5198 mL
100 mM0.0452 mL0.2260 mL0.4520 mL2.2599 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Ubiquitin ligaseUbiquitin conjugating enzymeUbiquitin activating enzymeNLRP3Inhibitorinhibitinflammasome activationIL-1βIL-18hydrocotarnineglycolytic metabolismglycolytic capacityGLUT1E3 ligating enzymeE2 conjugating enzymeE1/E2/E3 EnzymeE1 activating enzymecellular glucose uptakeCblcancer pain
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