PD-L2 Protein, Cynomolgus, Recombinant (aa 20-220, His)

Catalog No. TMPK-01290

PD-1 ligand 2 (PD-L2) as a second ligand for PD-1 and compare the function and expression of PD-L1 and PD-L2. Engagement of PD-1 by PD-L2 dramatically inhibits T cell receptor (TCR)-mediated proliferation and cytokine production by CD4 T cells. At low antigen concentrations, PD-L2-PD-1 interactions inhibit strong B7-CD28 signals. PD-L2 Protein, Cynomolgus, Recombinant (aa 20-220, His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 23.73 kDa and the accession number is A0A2K5U5Z4.

PD-L2 Protein, Cynomolgus, Recombinant (aa 20-220, His)

Catalog No. TMPK-01290

Pack Size	Price	Availability
5 μg	$51	7-10 days
10 μg	$80	7-10 days
20 μg	$129	7-10 days
50 μg	$248	7-10 days
100 μg	$418	7-10 days
200 μg	$757	7-10 days
500 μg	$1,670	7-10 days

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Product Information

Biological Activity	Cynomolgus PD-1, hFc Tag captured on CM5 Chip via Protein A can bind Cynomolgus PD-L2, His Tag with an affinity constant of 0.17 μM as determined in SPR assay.
Description	PD-1 ligand 2 (PD-L2) as a second ligand for PD-1 and compare the function and expression of PD-L1 and PD-L2. Engagement of PD-1 by PD-L2 dramatically inhibits T cell receptor (TCR)-mediated proliferation and cytokine production by CD4 T cells. At low antigen concentrations, PD-L2-PD-1 interactions inhibit strong B7-CD28 signals. PD-L2 Protein, Cynomolgus, Recombinant (aa 20-220, His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 23.73 kDa and the accession number is A0A2K5U5Z4.
Species	Cynomolgus
Expression System	HEK293 Cells
Tag	C-His
Accession Number	A0A2K5U5Z4
Synonyms	PD-L2,PDL2,PDCD1LG2,PDCD1L2,CD273, PDCD1 ligand 2,Butyrophilin B7-DC,Btdc,bA574F11.2,B7DC
Construction	Leu20-Thr220
Protein Purity	> 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC
Molecular Weight	23.73 kDa (predicted). Due to glycosylation, the protein migrates to 40-50 kDa based on Tris-Bis PAGE result.
Endotoxin	< 1 EU/μg by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS (pH 7.4). Typically, 8% trehalose is incorporated as a protective agent before lyophilization.
Reconstitution	Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
Stability & Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, Lyophilized powders are shipping with blue ice.
Research Background	PD-1 ligand 2 (PD-L2) as a second ligand for PD-1 and compare the function and expression of PD-L1 and PD-L2. Engagement of PD-1 by PD-L2 dramatically inhibits T cell receptor (TCR)-mediated proliferation and cytokine production by CD4 T cells. At low antigen concentrations, PD-L2-PD-1 interactions inhibit strong B7-CD28 signals.