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Mupirocin

Name: Mupirocin
Brand: TargetMol
SKU: T1465
Price: 32 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1465Cas No. 12650-69-0

Alias Pseudomonic acid, BRL-4910A

Mupirocin (BRL-4910A) is a RNA synthetase inhibitor antibacterial. It has shown excellent activity against gram-positive staphylococci and streptococci.

Mupirocin

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Purity: 97.46%

Catalog No. T1465Alias Pseudomonic acid, BRL-4910ACas No. 12650-69-0

Mupirocin (BRL-4910A) is a RNA synthetase inhibitor antibacterial. It has shown excellent activity against gram-positive staphylococci and streptococci.

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$32	In Stock	In Stock
25 mg	$67	In Stock	In Stock
50 mg	$103	In Stock	In Stock
100 mg	$163	In Stock	In Stock
500 mg	$375	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:97.46%

Color:White

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COA HNMR LCMS

Product Introduction

Mupirocin AI Summary

Mupirocin exhibits broad-spectrum antibacterial activity against a variety of bacterial strains, including Staphylococcus aureus, Streptococcus pyogenes, Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis, with minimum inhibitory concentrations (MIC) ranging from <= 0.06 to 0.25 ug/mL. It demonstrates potent effects against methicillin-resistant Staphylococcus aureus (MRSA), with MIC values as low as 0.12 ug/mL for some strains. Additionally, Mupirocin has been shown to inhibit isoleucyl-tRNA synthetase with IC50 values as low as 0.8 nM and competitive inhibition (Ki = 2.5 nM). Notably, it also displays significant activity against mupirocin-susceptible MRSA and has shown efficacy in a BALB/c mouse model of skin infection caused by MRSA. However, its efficacy against gram-negative Bacilli species and certain other strains such as Pseudomonas aeruginosa and Klebsiella pneumoniae is relatively limited, with higher MIC values. The compound demonstrates low cytotoxicity against human cells, and it has shown minimal potential for liver-related toxicity. Mupirocin also exhibits antiviral and antifungal activities, though with varying degrees of efficacy across different pathogens..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Mupirocin (BRL-4910A) is a RNA synthetase inhibitor antibacterial. It has shown excellent activity against gram-positive staphylococci and streptococci.
Synonyms	Pseudomonic acid, BRL-4910A

Chemical Properties

Molecular Weight	500.62
Formula	C₂₆H₄₄O₉
Cas No.	12650-69-0
Smiles	C([C@H]1[C@]([C@H]([C@H](C)O)C)(O1)[H])[C@@H]2[C@@H](O)[C@@H](O)[C@H](C/C(=C/C(OCCCCCCCCC(O)=O)=O)/C)OC2
Relative Density.	1.183 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 93 mg/mL (185.77 mM), Sonication is recommended.

H2O: 42 mg/mL (83.9 mM), Sonication is recommended.

DMSO: 240 mg/mL (479.41 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (9.99 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9975 mL	9.9876 mL	19.9752 mL	99.8762 mL
5 mM	0.3995 mL	1.9975 mL	3.9950 mL	19.9752 mL
10 mM	0.1998 mL	0.9988 mL	1.9975 mL	9.9876 mL
20 mM	0.0999 mL	0.4994 mL	0.9988 mL	4.9938 mL
50 mM	0.0400 mL	0.1998 mL	0.3995 mL	1.9975 mL

Ethanol/DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0200 mL	0.0999 mL	0.1998 mL	0.9988 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc