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AT-1001 (Synonyms: AT 1001)

Name: AT-1001
Brand: TargetMol
SKU: T70987
Price: 59 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T70987 Copy Product Info

Purity: 98.26%

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AT-1001 (Larazotide) is an orally active tight junction regulator and Zonulin antagonist. It reduces intestinal permeability in celiac and inflammatory bowel disease models by blocking Zonulin receptor signaling to maintain the integrity of epithelial tight junctions.

AT-1001

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Catalog No. T70987

Synonyms AT 1001

Cas No. 1314801-63-2

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Pack Size	Price	USA Stock	Global Stock
1 mg	$59	-	In Stock
5 mg	$143	-	In Stock
10 mg	$228	-	In Stock
25 mg	$463	-	In Stock
50 mg	$569	-	In Stock
1 mL x 10 mM (in DMSO)	$158	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:98.26%

Appearance:Solid

Color:Brown

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Product Introduction

Bioactivity

Description	AT-1001 (Larazotide) is an orally active tight junction regulator and Zonulin antagonist. It reduces intestinal permeability in celiac and inflammatory bowel disease models by blocking Zonulin receptor signaling to maintain the integrity of epithelial tight junctions.
In vitro	AT-1001 dose-dependently and reversibly blocks alpha3beta4 nAChR-mediated currents, showing high subtype specificity [1].
In vivo	AT-1001 inhibits nicotine self-administration in rats without affecting food reinforcement [1].
Synonyms	AT 1001

Chemical Properties

Molecular Weight	309.24
Formula	C₁₅H₂₁BrN₂
Cas No.	1314801-63-2
Smiles	N([C@H]1C[C@@]2(N(C)[C@](C1)(CCC2)[H])[H])C3=C(Br)C=CC=C3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (129.35 mM), Sonication is recommmended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2337 mL	16.1687 mL	32.3373 mL	161.6867 mL
5 mM	0.6467 mL	3.2337 mL	6.4675 mL	32.3373 mL
10 mM	0.3234 mL	1.6169 mL	3.2337 mL	16.1687 mL
20 mM	0.1617 mL	0.8084 mL	1.6169 mL	8.0843 mL
50 mM	0.0647 mL	0.3234 mL	0.6467 mL	3.2337 mL
100 mM	0.0323 mL	0.1617 mL	0.3234 mL	1.6169 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc