Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Rovanersen (WVE-120101) is an antisense oligonucleotide that can be used for huntington’s disease research.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | Inquiry | $ 614.00 |
Description | Rovanersen (WVE-120101) is an antisense oligonucleotide that can be used for huntington’s disease research. |
In vitro | In vitro, Rovanersen (WVE-120101) selectively facilitates RNase H-mediated cleavage of the mutant Huntingtin allele (mHTT) over the wild-type HTT (wtHTT), without activating the complement system. Additionally, Rovanersen specifically reduces mRNA and protein levels of mHTT compared to wtHTT across various cell lines[1]. |
In vivo | In non-human primates (NHPs), Rovanersen (WVE-120101) localizes to the nuclear and perinuclear regions of neurons within brain areas implicated in Huntington’s disease (HD) pathology[1]. |
Synonyms | WVE-120101, Rovanersen |
Molecular Weight | N/A |
CAS No. | 2072901-32-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
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Rovanersen 2072901-32-5 WVE 120101 WVE-120101 WVE120101 inhibitor inhibit