Contact UsQuotation
Shopping Cart
Remove All
  • TargetMol
    Your shopping cart is currently empty
Proceed to checkoutContinue shopping
TOPBioactivityChemical infoStorage&SolubilityCalculator

QS-21

😃Good
Catalog No. T38838Cas No. 141256-04-4
Alias Stimulon, QS-21

QS-21, an immunostimulatory saponin, is a potent vaccine adjuvant that stimulates both Th2 humoral and Th1 cell-mediated immune responses by interacting with antigen presenting cells (APCs) and T cells. Furthermore, QS-21 activates the NLRP3 inflammasome, leading to the release of cytokines IL-1β and IL-18, dependent on caspase-1.

QS-21

QS-21

😃Good
Catalog No. T38838Alias Stimulon, QS-21Cas No. 141256-04-4
QS-21, an immunostimulatory saponin, is a potent vaccine adjuvant that stimulates both Th2 humoral and Th1 cell-mediated immune responses by interacting with antigen presenting cells (APCs) and T cells. Furthermore, QS-21 activates the NLRP3 inflammasome, leading to the release of cytokines IL-1β and IL-18, dependent on caspase-1.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
10 mg$3,8507-10 days7-10 days
Add to Cart
Add to Quotation
In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Questions
TargetMol
View More

Resource Download

Product Introduction

Bioactivity
Description
QS-21, an immunostimulatory saponin, is a potent vaccine adjuvant that stimulates both Th2 humoral and Th1 cell-mediated immune responses by interacting with antigen presenting cells (APCs) and T cells. Furthermore, QS-21 activates the NLRP3 inflammasome, leading to the release of cytokines IL-1β and IL-18, dependent on caspase-1.
In vivo
Research on mouse antigen-presenting cells (APCs), specifically dendritic cells (DCs) and macrophages, has identified QS-21 as a stimulant for the NLRP3 inflammasome. This activation leads to the subsequent release of caspase-1-dependent proinflammatory cytokines, IL-1β/IL-18, which either support the maturation of Th17 cells or energize interferon-gamma (INF-γ)-mediated Th1 responses, respectively[3].
SynonymsStimulon, QS-21
Chemical Properties
Molecular Weight1990.15
FormulaC92H148O46
Cas No.141256-04-4
Smiles[H][C@@](C[C@H](O)CC(=O)O[C@@]([H])(C[C@H](O)CC(=O)O[C@H]1[C@@H](C)O[C@@H](OC(=O)[C@]23CCC(C)(C)C[C@@]2([H])C2=CC[C@]4([H])[C@@]5(C)CC[C@H](O[C@]6([H])O[C@@H]([C@@H](O)[C@H](O[C@]7([H])OC[C@@H](O)[C@H](O)[C@H]7O)[C@H]6O[C@]6([H])O[C@H](CO)[C@H](O)[C@H](O)[C@H]6O)C(O)=O)[C@@](C)(C=O)[C@]5([H])CC[C@@]4(C)[C@]2(C)C[C@H]3O)[C@H](O[C@]2([H])O[C@@H](C)[C@H](O[C@]3([H])OC[C@@H](O)[C@H](O[C@]4([H])OC[C@](O)(CO)[C@H]4O)[C@H]3O)[C@@H](O)[C@H]2O)[C@H]1O)[C@@H](C)CC)(O[C@@H]1O[C@@H](CO)[C@H](O)[C@H]1O)[C@@H](C)CC
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Calculator

  • Molarity Calculator
  • Dilution Calculator
  • Reconstitution Calculator
  • Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

QS21QS 21
Related Tags: buy QS-21 | purchase QS-21 | QS-21 cost | order QS-21 | QS-21 chemical structure | QS-21 in vivo | QS-21 formula | QS-21 molecular weight
TargetMol | Logo

Copyright © 2015-2026 TargetMol Chemicals Inc. All Rights Reserved.