Powder: -20°C for 3 years | In solvent: -80°C for 1 year
QS-21, an immunostimulatory saponin, is a powerful vaccine adjuvant that stimulates both Th2 humoral and Th1 cell-mediated immune responses by interacting with antigen presenting cells (APCs) and T cells. Additionally, QS-21 activates the NLRP3 inflammasome, leading to the release of cytokines IL-1β and IL-18, which are dependent on caspase-1.
Pack Size | Availability | Price/USD | Quantity |
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10 mg | Inquiry | $ 598.00 |
Description | QS-21, an immunostimulatory saponin, is a powerful vaccine adjuvant that stimulates both Th2 humoral and Th1 cell-mediated immune responses by interacting with antigen presenting cells (APCs) and T cells. Additionally, QS-21 activates the NLRP3 inflammasome, leading to the release of cytokines IL-1β and IL-18, which are dependent on caspase-1. |
In vivo | Research on mouse antigen-presenting cells (APCs), specifically dendritic cells (DCs) and macrophages, has identified QS-21 as a stimulant for the NLRP3 inflammasome. This activation leads to the subsequent release of caspase-1-dependent proinflammatory cytokines, IL-1β/IL-18, which either support the maturation of Th17 cells or energize interferon-gamma (INF-γ)-mediated Th1 responses, respectively[3]. |
Synonyms | Stimulon, QS-21 |
Molecular Weight | 1990.15 |
Formula | C92H148O46 |
CAS No. | 141256-04-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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QS-21 141256-04-4 Stimulon QS21 QS 21 inhibitor inhibit