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NE-100 hydrochloride

Name: NE-100 hydrochloride
Brand: TargetMol
SKU: T20797
Price: 38 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T20797Cas No. 149409-57-4

Alias NE-100 Hydrochloride, NE100 Hydrochloride, NE-100 HCl, NE 100 Hydrochloride, NE 100 HCl

NE-100 hydrochloride (NE-100 HCl) is a potent and selective antagonist of σ1 (IC50 = 4.16 nM) with antipsychotic activity. NE100 HCl also suppresses ER stress-induced hippocampal cell death.

NE-100 hydrochloride

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Purity: 99.76%

Catalog No. T20797Alias NE-100 Hydrochloride, NE100 Hydrochloride, NE-100 HCl, NE 100 Hydrochloride, NE 100 HClCas No. 149409-57-4

NE-100 hydrochloride (NE-100 HCl) is a potent and selective antagonist of σ1 (IC50 = 4.16 nM) with antipsychotic activity. NE100 HCl also suppresses ER stress-induced hippocampal cell death.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$38	In Stock	In Stock
2 mg	$52	In Stock	In Stock
5 mg	$84	In Stock	In Stock
10 mg	$139	In Stock	In Stock
25 mg	$233	In Stock	In Stock
50 mg	$347	In Stock	In Stock
100 mg	$516	-	In Stock
200 mg	$736	-	In Stock
500 mg	$1,090	6-8 weeks	6-8 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.76%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

NE-100 hydrochloride AI Summary

NE-100 hydrochloride exhibits high binding affinity for the Sigma opioid receptors, specifically Sigma receptor type 1 with an IC50 of 1.3 nM in both guinea pig and rat brain membranes. It also binds to the Sigma receptor type 2 with IC50 values of 1.5 nM and 212.0 nM, depending on the study. The compound demonstrates significantly lower affinity towards Dopamine receptor D2, 5-hydroxytryptamine 1A receptor, and Alpha-1 adrenergic receptor with IC50 values greater than 1000.0 nM, 6460.0 nM, and 10800.0 nM, respectively. Additionally, NE-100 hydrochloride shows no significant affinity for the serotonin transporter (SERT) and dopamine transporter (DAT). Pharmacologically, it reduces SKF-10047-induced stereotyped behavior in mice and inhibits methamphetamine-induced hyperlocomotion at an intraperitoneal dose of 10 mg/kg. Moreover, NE-100 hydrochloride displays antiviral activity against SARS-CoV-2 by inhibiting the virus’s cytotoxic effects on Caco-2 and VERO-6 cells at a 10 µM concentration after 48 hours, though the inhibition rates are somewhat limited. It also inhibits the SARS-CoV-2 3CL-Pro protease with 15.96% inhibition at a 20µM concentration..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	NE-100 hydrochloride (NE-100 HCl) is a potent and selective antagonist of σ1 (IC50 = 4.16 nM) with antipsychotic activity. NE100 HCl also suppresses ER stress-induced hippocampal cell death.
Targets&IC50	σ1 receptor:4.16 nM
Synonyms	NE-100 Hydrochloride, NE100 Hydrochloride, NE-100 HCl, NE 100 Hydrochloride, NE 100 HCl

Chemical Properties

Molecular Weight	391.98
Formula	C₂₃H₃₄ClNO₂
Cas No.	149409-57-4
Smiles	Cl.CCCN(CCC)CCc1ccc(OC)c(OCCc2ccccc2)c1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (637.79 mM), Sonication is recommended.

H2O: 15 mg/mL (38.27 mM), Sonication and heating to 60℃ are recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5512 mL	12.7558 mL	25.5115 mL	127.5575 mL
5 mM	0.5102 mL	2.5512 mL	5.1023 mL	25.5115 mL
10 mM	0.2551 mL	1.2756 mL	2.5512 mL	12.7558 mL
20 mM	0.1276 mL	0.6378 mL	1.2756 mL	6.3779 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0510 mL	0.2551 mL	0.5102 mL	2.5512 mL
100 mM	0.0255 mL	0.1276 mL	0.2551 mL	1.2756 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc