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NE-100 hydrochloride

🥰Excellent
Catalog No. T20797Cas No. 149409-57-4
Alias NE-100 Hydrochloride, NE100 Hydrochloride, NE-100 HCl, NE 100 Hydrochloride, NE 100 HCl

NE-100 hydrochloride (NE-100 HCl) is a potent and selective antagonist of σ1 (IC50 = 4.16 nM) with antipsychotic activity. NE100 HCl also suppresses ER stress-induced hippocampal cell death.

NE-100 hydrochloride

NE-100 hydrochloride

🥰Excellent
Purity: 99.76%
Catalog No. T20797Alias NE-100 Hydrochloride, NE100 Hydrochloride, NE-100 HCl, NE 100 Hydrochloride, NE 100 HClCas No. 149409-57-4
NE-100 hydrochloride (NE-100 HCl) is a potent and selective antagonist of σ1 (IC50 = 4.16 nM) with antipsychotic activity. NE100 HCl also suppresses ER stress-induced hippocampal cell death.
Pack SizePriceAvailabilityQuantity
1 mg$38In Stock
2 mg$52In Stock
5 mg$84In Stock
10 mg$139In Stock
25 mg$233In Stock
50 mg$347In Stock
100 mg$516In Stock
200 mg$736In Stock
500 mg$1,090In Stock
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Purity:99.76%
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COA HNMR LCMS

Product Introduction

Bioactivity
Description
NE-100 hydrochloride (NE-100 HCl) is a potent and selective antagonist of σ1 (IC50 = 4.16 nM) with antipsychotic activity. NE100 HCl also suppresses ER stress-induced hippocampal cell death.
Targets&IC50
σ1 receptor:4.16 nM
SynonymsNE-100 Hydrochloride, NE100 Hydrochloride, NE-100 HCl, NE 100 Hydrochloride, NE 100 HCl
Chemical Properties
Molecular Weight391.98
FormulaC23H34ClNO2
Cas No.149409-57-4
SmilesCl.CCCN(CCC)CCc1ccc(OC)c(OCCc2ccccc2)c1
Relative Density.no data available
ColorWhite
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: Soluble
H2O: 15 mg/mL (38.27 mM), Sonication and heating to 60℃ are recommended.
Solution Preparation Table
H2O
1mg5mg10mg50mg
1 mM2.5512 mL12.7558 mL25.5115 mL127.5575 mL
5 mM0.5102 mL2.5512 mL5.1023 mL25.5115 mL
10 mM0.2551 mL1.2756 mL2.5512 mL12.7558 mL
20 mM0.1276 mL0.6378 mL1.2756 mL6.3779 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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Keywords

σ1SigmareceptorSigma ReceptorSigma receptorNE100 hydrochloride NE-100NE100NE 100 hydrochloride NE 100Inhibitorinhibit
Related Tags: buy NE-100 hydrochloride | purchase NE-100 hydrochloride | NE-100 hydrochloride cost | order NE-100 hydrochloride | NE-100 hydrochloride chemical structure | NE-100 hydrochloride formula | NE-100 hydrochloride molecular weight
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