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Azelastine hydrochloride

🥰Excellent
Catalog No. T0211LCas No. 79307-93-0
Alias Optivar, Azelastine HCl, Astelin, Allergodil

Azelastine hydrochloride (Astelin) is a phthalazinone derivative with antihistaminergic activity.

Azelastine hydrochloride
Other Forms of Azelastine hydrochloride:

Azelastine hydrochloride

🥰Excellent
Purity: 99.97%
Catalog No. T0211LAlias Optivar, Azelastine HCl, Astelin, AllergodilCas No. 79307-93-0
Azelastine hydrochloride (Astelin) is a phthalazinone derivative with antihistaminergic activity.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
50 mg$30In StockIn Stock
1 mL x 10 mM (in DMSO)$45In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.97%
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COA HNMR LCMS

Product Introduction

Bioactivity
Description
Azelastine hydrochloride (Astelin) is a phthalazinone derivative with antihistaminergic activity.
In vivo
In the rat basophilic leukemia RBL-2H3 cell line, Azelastine inhibited antigen (Ag)-induced TNF-alpha release (IC50=25.7 mM) and ionomycin-induced TNF-alpha release (IC50=1.66 mM). In mouse peritoneal macrophages, Azelastine suppressed inducible nitric oxide synthase (iNOS) mRNA expression and nitric oxide (NO) production. In normal human mast cells, Azelastine inhibited the secretion of IL-6, TNF-alpha, and IL-8, and the activation of NF-κB, as well as intracellular calcium levels. In human gingival fibroblasts, Azelastine dose-dependently inhibited DNA and protein synthesis.
SynonymsOptivar, Azelastine HCl, Astelin, Allergodil
Chemical Properties
Molecular Weight418.36
FormulaC22H24ClN3O·HCl
Cas No.79307-93-0
SmilesCl.CN1CCCC(CC1)n1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O
Relative Density.1.25 g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 84 mg/mL (200.78 mM), Sonication is recommended.
H2O: 35 mg/mL (83.66 mM), Sonication is recommended.
Ethanol: 57 mg/mL (136.25 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (7.89 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
H2O/Ethanol/DMSO
1mg5mg10mg50mg
1 mM2.3903 mL11.9514 mL23.9029 mL119.5143 mL
5 mM0.4781 mL2.3903 mL4.7806 mL23.9029 mL
10 mM0.2390 mL1.1951 mL2.3903 mL11.9514 mL
20 mM0.1195 mL0.5976 mL1.1951 mL5.9757 mL
50 mM0.0478 mL0.2390 mL0.4781 mL2.3903 mL
Ethanol/DMSO
1mg5mg10mg50mg
100 mM0.0239 mL0.1195 mL0.2390 mL1.1951 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
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Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

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