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Azelastine hydrochloride (Alias: Optivar, Azelastine HCl, Astelin, Allergodil)

Name: Azelastine hydrochloride
Brand: TargetMol
SKU: T0211L
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T0211L Copy Product Info

Purity: 99.97%

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Azelastine hydrochloride (Astelin) is a phthalazinone derivative with antihistaminergic activity.

Azelastine hydrochloride

Copy Product Info

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Catalog No. T0211L

Alias Optivar, Azelastine HCl, Astelin, Allergodil

Azelastine hydrochloride (Astelin) is a phthalazinone derivative with antihistaminergic activity.

Cas No. 79307-93-0

Pack Size	Price	USA Stock	Global Stock	Quantity
50 mg	$30	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$45	In Stock	In Stock

In stock · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.97%

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Azelastine hydrochloride (Astelin) is a phthalazinone derivative with antihistaminergic activity.
In vivo	In the rat basophilic leukemia RBL-2H3 cell line, Azelastine inhibited antigen (Ag)-induced TNF-alpha release (IC50=25.7 mM) and ionomycin-induced TNF-alpha release (IC50=1.66 mM). In mouse peritoneal macrophages, Azelastine suppressed inducible nitric oxide synthase (iNOS) mRNA expression and nitric oxide (NO) production. In normal human mast cells, Azelastine inhibited the secretion of IL-6, TNF-alpha, and IL-8, and the activation of NF-κB, as well as intracellular calcium levels. In human gingival fibroblasts, Azelastine dose-dependently inhibited DNA and protein synthesis.
Synonyms	Optivar, Azelastine HCl, Astelin, Allergodil

Chemical Properties

Molecular Weight	418.36
Formula	C₂₂H₂₄ClN₃O·HCl
Cas No.	79307-93-0
Smiles	Cl.CN1CCCC(CC1)n1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O
Relative Density.	1.25 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 84 mg/mL (200.78 mM), Sonication is recommended.

H2O: 35 mg/mL (83.66 mM), Sonication is recommended.

Ethanol: 57 mg/mL (136.25 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (7.89 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3903 mL	11.9514 mL	23.9029 mL	119.5143 mL
5 mM	0.4781 mL	2.3903 mL	4.7806 mL	23.9029 mL
10 mM	0.2390 mL	1.1951 mL	2.3903 mL	11.9514 mL
20 mM	0.1195 mL	0.5976 mL	1.1951 mL	5.9757 mL
50 mM	0.0478 mL	0.2390 mL	0.4781 mL	2.3903 mL

Ethanol/DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0239 mL	0.1195 mL	0.2390 mL	1.1951 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc