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Anti-SIRT2 Antibody (2O767)

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Catalog No. TMAB-12814

Anti-SIRT2 Antibody (2O767) is a Rabbit antibody targeting SIRT2. Anti-SIRT2 Antibody (2O767) can be used in WB,IHC-P,IHC-Fr,IF.

Anti-SIRT2 Antibody (2O767)

Anti-SIRT2 Antibody (2O767)

😃Good
Catalog No. TMAB-12814
Anti-SIRT2 Antibody (2O767) is a Rabbit antibody targeting SIRT2. Anti-SIRT2 Antibody (2O767) can be used in WB,IHC-P,IHC-Fr,IF.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
50 μL$2647-10 days7-10 days
100 μL$4707-10 days7-10 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Anti-SIRT2 Antibody (2O767) is a Rabbit antibody targeting SIRT2. Anti-SIRT2 Antibody (2O767) can be used in WB,IHC-P,IHC-Fr,IF.
Ig Type
IgG
Clone
2O767
Reactivity
Human,Mouse,Rat
Application
WB
IHC-P
IHC-Fr
IF
Recommended Dose
WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
Antibody Type
Monoclonal
Host SpeciesRabbit
Subcellular LocalizationCytoplasm, cytoskeleton. Colocalizes with microtubules.
Tissue SpecificityWidely expressed. Highly expressed in heart, brain and skeletal muscle, while it is weakly expressed in placenta and lung. Down-regulated in many gliomas suggesting that it may act as a tumor suppressor gene in human gliomas possibly through the regulation of microtubule network.
ConstructionRecombinant Antibody
PurificationProtein A purified
AppearanceLiquid
Formulation0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration1mg/ml
Research BackgroundThis gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Several transcript variants are resulted from alternative splicing of this gene. [provided by RefSeq, Jul 2010]
Antigen Details
Immunogen
A synthesized peptide: human SIRT2
Antigen Species
Human
Gene Name
SIRT2
Gene ID
22933
Protein Name
NAD-dependent protein deacetylase sirtuin-2
Uniprot ID
Q8IXJ6
Function
NAD-dependent protein deacetylase, which deacetylates the 'Lys-40' of alpha-tubulin. Involved in the control of mitotic exit in the cell cycle, probably via its role in the regulation of cytoskeleton.
Chemical Properties
Molecular WeightTheoretical: 36 kDa.
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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