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Ketohexokinase inhibitor 1

Name: Ketohexokinase inhibitor 1
Brand: TargetMol
SKU: T15654
Price: 129 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T15654Cas No. 2102501-84-6

Alias PF-06835919

Ketohexokinase inhibitor 1 is a ketohexokinase inhibitor (IC50s: 8.4 nM and 66 nM for KHK-C and KHK-A, respectively).

Ketohexokinase inhibitor 1

🥰Excellent

Purity: 99.66%

Catalog No. T15654Alias PF-06835919Cas No. 2102501-84-6

Ketohexokinase inhibitor 1 is a ketohexokinase inhibitor (IC50s: 8.4 nM and 66 nM for KHK-C and KHK-A, respectively).

Pack Size	Price	Availability
1 mg	$129	In Stock
5 mg	$389	In Stock
10 mg	$652	In Stock
25 mg	$1,170	In Stock
50 mg	$1,590	In Stock
100 mg	$2,150	In Stock
200 mg	$2,880	In Stock
1 mL x 10 mM (in DMSO)	$428	In Stock

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Batch Information

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Purity:99.66%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	Ketohexokinase inhibitor 1 is a ketohexokinase inhibitor (IC50s: 8.4 nM and 66 nM for KHK-C and KHK-A, respectively).
Targets&IC50	KHK-C:8.4 nM, KHK-A:66 nM
Synonyms	PF-06835919

Chemical Properties

Molecular Weight	356.34
Formula	C₁₆H₁₉F₃N₄O₂
Cas No.	2102501-84-6
Smiles	C(C(O)=O)[C@@H]1[C@@]2([C@]1(CN(C2)C3=NC(=NC(C(F)(F)F)=C3)N4[C@@H](C)CC4)[H])[H]
Relative Density.	1.415 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 125 mg/mL (350.79 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8063 mL	14.0315 mL	28.0631 mL	140.3154 mL
5 mM	0.5613 mL	2.8063 mL	5.6126 mL	28.0631 mL
10 mM	0.2806 mL	1.4032 mL	2.8063 mL	14.0315 mL
20 mM	0.1403 mL	0.7016 mL	1.4032 mL	7.0158 mL
50 mM	0.0561 mL	0.2806 mL	0.5613 mL	2.8063 mL
100 mM	0.0281 mL	0.1403 mL	0.2806 mL	1.4032 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc