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Ketohexokinase inhibitor 1

Name: Ketohexokinase inhibitor 1
Brand: TargetMol
SKU: T15654
Price: 106 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15654Cas No. 2102501-84-6

Alias PF-06835919

Ketohexokinase inhibitor 1 is a ketohexokinase inhibitor (IC50s: 8.4 nM and 66 nM for KHK-C and KHK-A, respectively).

Ketohexokinase inhibitor 1

😃Good

Purity: 99.66%

Catalog No. T15654Alias PF-06835919Cas No. 2102501-84-6

Ketohexokinase inhibitor 1 is a ketohexokinase inhibitor (IC50s: 8.4 nM and 66 nM for KHK-C and KHK-A, respectively).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$106	In Stock	In Stock
2 mg	$168	In Stock	In Stock
5 mg	$322	In Stock	In Stock
10 mg	$546	In Stock	In Stock
25 mg	$977	In Stock	In Stock
50 mg	$1,320	In Stock	In Stock
100 mg	$1,780	-	In Stock
200 mg	$2,380	-	In Stock
1 mL x 10 mM (in DMSO)	$353	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

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Purity:99.66%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	Ketohexokinase inhibitor 1 is a ketohexokinase inhibitor (IC50s: 8.4 nM and 66 nM for KHK-C and KHK-A, respectively).
Targets&IC50	KHK-C:8.4 nM, KHK-A:66 nM
Synonyms	PF-06835919

Chemical Properties

Molecular Weight	356.34
Formula	C₁₆H₁₉F₃N₄O₂
Cas No.	2102501-84-6
Smiles	C(C(O)=O)[C@@H]1[C@@]2([C@]1(CN(C2)C3=NC(=NC(C(F)(F)F)=C3)N4[C@@H](C)CC4)[H])[H]
Relative Density.	1.415 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 125 mg/mL (350.79 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (11.23 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8063 mL	14.0315 mL	28.0631 mL	140.3154 mL
5 mM	0.5613 mL	2.8063 mL	5.6126 mL	28.0631 mL
10 mM	0.2806 mL	1.4032 mL	2.8063 mL	14.0315 mL
20 mM	0.1403 mL	0.7016 mL	1.4032 mL	7.0158 mL
50 mM	0.0561 mL	0.2806 mL	0.5613 mL	2.8063 mL
100 mM	0.0281 mL	0.1403 mL	0.2806 mL	1.4032 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc